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Walk the evidence base by book and chapter — the raw source passages that ground Ask, Differential, and the rest.
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PET is not recommended for the diagnosis of sentinel lymph node micrometastatic disease or for staging of stage I, IIa, or IIb melanoma. Nine primary studies in the health technology assessment review and three primary studies from the 2005-2008 update evaluated PET or PET/CT as an adjunct to lymphatic staging in patients with primary melanoma. The sensitivity of PET was too low to detect sentinel node metastases in early-stage melanoma (sensitivity range 0% to 22%). The routine use of PET or PET/CT is not recommended for the diagnosis of brain metastases. The routine use of PET is not recommended for the detection of primary uveal malignant melanoma. One primary study showed that single photon emission computed tomography was superior to PET for detection of uveal melanoma. The sensitivity of PET was 11%.