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Walk the evidence base by book and chapter — the raw source passages that ground Ask, Differential, and the rest.

• A multicenter RCT of noninvasive ventilation in pneumonia-induced early mild acute respiratory distress syndrome1 passage
• A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome1 passage
• A systematic review of biomarkers multivariately associated with acute respiratory distress syndrome development and mortality1 passage
• Acute kidney injury in burn patients admitted to the intensive care unit: a systematic review and meta-analysis1 passage
• Andexanet alpha versus four-factor prothrombin complex concentrate in DOACs anticoagulation reversal: an updated systematic review and meta-analysis15 passages
• Anticoagulation options for continuous renal replacement therapy in critically ill patients: a systematic review and network meta-analysis of randomized controlled trials1 passage
• Buprenorphine to reverse respiratory depression from methadone overdose in opioid-dependent patients: a prospective randomized trial1 passage
• Cardiac output monitors in septic shock: do they deliver what matters? A systematic review and meta-analysis1 passage
• Cefepime-induced neurotoxicity: a systematic review1 passage
• Changes in pulse pressure variation induced by passive leg raising test to predict preload responsiveness in mechanically ventilated patients with low tidal volume in ICU: a systematic review and meta-analysis1 passage
• Clinical utility of proenkephalin A 119-159 for prediction of worsening renal function and prognosis in patients with sepsis -results of a patient-level meta-analysis1 passage
• Comparative accuracy of biomarkers for the prediction of hospital-acquired acute kidney injury: a systematic review and meta-analysis1 passage
• Comparison of culture-negative and culture-positive sepsis or septic shock: a systematic review and meta-analysis1 passage
• Comparison of two transpulmonary pressure-based positive end-expiratory pressure titration strategies in acute respiratory distress syndrome: a randomized crossover study1 passage
• Complications in acute respiratory distress syndrome: a systematic review and meta-analysis1 passage
• Composition and diversity of the pulmonary microbiome in acute respiratory distress syndrome: a systematic review1 passage
• Corticosteroids in septic shock: a systematic review and network meta-analysis1 passage
• Corticotropin-stimulated steroid profiles to predict shock development and mortality in sepsis: From the HYPRESS study1 passage
• Decreased mortality in acute respiratory distress syndrome patients treated with corticosteroids: an updated meta-analysis of randomized clinical trials with trial sequential analysis1 passage
• Definition and prognostic value of response to prone positioning in ARDS: a systematic review and meta-analysis1 passage
• Diagnostic accuracy of lung ultrasound in diagnosis of ARDS and identification of focal or non-focal ARDS subphenotypes: a systematic review and meta-analysis1 passage
• Driving pressure-limited ventilation strategies versus conventional lung protective ventilation strategies for patients with ARDS/ARF: a systematic review and meta-analysis of randomized controlled trials1 passage
• Early adjunctive methylene blue in patients with septic shock: a randomized controlled trial1 passage
• Early administration of vitamin C in patients with sepsis or septic shock in emergency departments: a multicenter, double-blind, randomized controlled trial: the C-EASIE trial1 passage
• Early high-sensitivity troponin elevation and short-term mortality in sepsis: a systematic review with meta-analysis1 passage
• Early individualized positive end-expiratory pressure guided by electrical impedance tomography in acute respiratory distress syndrome: a randomized controlled clinical trial1 passage
• Early norepinephrine for patients with septic shock: an updated systematic review and meta-analysis with trial sequential analysis1 passage
• Effect of decompressive laparotomy on organ function in patients with abdominal compartment syndrome: a systematic review and meta-analysis1 passage
• Effect of driving pressure on mortality in ARDS patients during lung protective mechanical ventilation in two randomized controlled trials1 passage
• Effect of driving pressure-limiting strategies on outcomes of patients with ARDS: a meta-analysis of randomized controlled trials1 passage
• Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care unit patients with infection and sepsis patients: a patient-level meta-analysis of randomized trials1 passage
• Effectiveness and safety of prolonged prone positioning in adult patients with acute respiratory distress syndrome (ARDS): a systematic review and meta-analysis1 passage
• Efficacy of delivery of care with Tele-continuous EEG in critically ill patients: a multicenter randomized controlled trial (Tele-cRCT study) study1 passage
• Efficacy of higher-dose versus lower-dose corticosteroids in community-acquired pneumonia: a systematic review and network meta-analysis1 passage
• Elastance as a determinant of the effect of prone positioning on mortality in acute respiratory distress syndrome: a post hoc analysis of the PROSEVA trial1 passage
• Extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis1 passage
• Extracorporeal treatment for ethylene glycol poisoning: systematic review and recommendations from the EXTRIP workgroup1 passage
• Fluid management for sepsis-induced hypotension in patients with advanced chronic kidney disease: a secondary analysis of the CLOVERS trial1 passage
• Furosemide stress test as a predictive marker of acute kidney injury progression or renal replacement therapy: a systemic review and meta-analysis1 passage
• Hemodynamic goal-directed therapy and postoperative kidney injury: an updated meta-analysis with trial sequential analysis1 passage
• Hyaluronic acid is associated with organ dysfunction in acute respiratory distress syndrome1 passage
• Intracranial multimodal monitoring in neurocritical care (Neurocore-iMMM): an open, decentralized consensus1 passage
• Intraoperative hemoadsorption and cardiac surgery-associated acute kidney injury: an updated systematic review and meta-analysis with trial sequential analysis1 passage
• Liberal transfusion strategies reduce sepsis risk and improve neurological recovery in acute brain injury: an updated systematic review and meta-analysis1 passage
• Longitudinal phenotypes in patients with acute respiratory distress syndrome: a multi-database study1 passage
• Lower versus standard dose-intensity continuous renal replacement therapy: a systematic review and meta-analysis1 passage
• Lung fluid biomarkers for acute respiratory distress syndrome: a systematic review and meta-analysis1 passage
• Mechanical ventilation in patients with acute brain injury: a systematic review with meta-analysis1 passage
• Mortality effect of albumin fluid resuscitation in adults with septic shock: a systematic review and dual frequentist-bayesian meta-analysis of randomised trials1 passage
• Mortality in sepsis and septic shock in Europe, North America and Australia between 2009 and 2019- results from a systematic review and meta-analysis1 passage
• Mortality in septic patients treated with vitamin C: a systematic meta-analysis1 passage
• Performance of the ROX index in predicting high flow nasal cannula failure in COVID-19 patients: a systematic review and meta-analysis1 passage
• Physiological effects of noninvasive respiratory support strategies in adults with acute hypoxemic respiratory failure: a systematic review and network meta-analysis1 passage
• Prehospital fibrinolysis versus primary percutaneous coronary intervention in ST-elevation myocardial infarction: a systematic review and meta-analysis of randomized controlled trials1 passage
• Prevalence and impact of acute renal impairment on COVID-19: a systematic review and meta-analysis1 passage
• Prevalence and incidence of cognitive impairment following acute respiratory distress syndrome of any cause: a systematic review and meta-analysis1 passage
• Prevalence and representation of comorbidities and multimorbidity in randomised controlled trials in sepsis or septic shock: a systematic review1 passage
• Prevention of cardiac surgery-associated acute kidney injury: a systematic review and meta-analysis of non-pharmacological interventions1 passage
• Proenkephalin as a biomarker correlates with acute kidney injury: a systematic review with meta-analysis and trial sequential analysis1 passage
• Prone positioning during venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis1 passage
• Protocolized natriuresis-guided diuretic therapy in acute heart failure: a systematic review and meta-analysis1 passage
• Randomized controlled trial: neostigmine for intra-abdominal hypertension in acute pancreatitis1 passage
• Remote ischemic conditioning reduces adverse events in patients with acute ischemic stroke complicating acute myocardial infarction: a randomized controlled trial1 passage
• Right dose, right now: bedside, real-time, data-driven, and personalised antibiotic dosing in critically ill patients with sepsis or septic shock-a two-centre randomised clinical trial1 passage
• Role of age as eligibility criterion for ECMO in patients with ARDS: meta-regression analysis1 passage
• Septic shock-3 vs 2: an analysis of the ALBIOS study1 passage
• Smoking on the risk of acute respiratory distress syndrome: a systematic review and meta-analysis1 passage
• Standard vs. carbone dioxide adapted kidney replacement therapy in hypercapnic ARDS patients: a randomized controlled pilot trial (BigBIC)1 passage
• The effects and safety of vasopressin receptor agonists in patients with septic shock: a meta-analysis and trial sequential analysis1 passage
• The influence of electronic AKI alert on prognosis of adult hospitalized patients: a systematic review and meta-analysis1 passage
• The prognostic utility of protein C as a biomarker for adult sepsis: a systematic review and meta-analysis1 passage
• Thoracic epidural analgesia in intensive care unit patients with acute pancreatitis: the EPIPAN multicenter randomized controlled trial1 passage
• Timing of renal replacement therapy initiation for acute kidney injury in critically ill patients: a systematic review of randomized clinical trials with meta-analysis and trial sequential analysis1 passage
• Treatment of COVID-19-associated ARDS with mesenchymal stromal cells: a multicenter randomized double-blind trial1 passage
• Valproic acid as adjuvant treatment for convulsive status epilepticus: a randomised clinical trial1 passage
• Value of variation of end-tidal carbon dioxide for predicting fluid responsiveness during the passive leg raising test in patients with mechanical ventilation: a systematic review and meta-analysis1 passage
• Venoarterial extracorporeal membrane oxygenation as mechanical circulatory support in adult septic shock: a systematic review and meta-analysis with individual participant data meta-regression analysis1 passage