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OBJECTIVE: This study aimed to examine whether isokinetic exercises applied to the intact wrist could reduce muscle strength loss and prevent the development of Complex Regional Pain Syndrome (CRPS) type I in adults with distal radius fractures. METHODS: Forty-two patients with distal radius fractures were randomized into two groups: a Cross-Education (CE) group (n = 21) and a control group (n = 21). Both groups received a standard home exercise program. In addition, the CE group performed 12 supervised sessions of isokinetic wrist strengthening exercises on the non-fractured side during the immobilization period. After cast removal, isometric muscle strength of the fractured wrist was evaluated, and patients were monitored for the development of CRPS type I. RESULTS: The CE group showed significantly higher isometric muscle strength in wrist flexors and extensors compared with the control group (wrist flexors: d = 0.73, p = 0.024; wrist extensors: d = 0.87, p = 0.008). Furthermore, the incidence of CRPS type I was significantly lower in the CE group (p = 0.03). CONCLUSION: Cross-Education training applied during immobilization can prevent muscle weakness and decrease the risk of CRPS in fracture rehabilitation. SIGNIFICANCE: These findings highlight CE as a safe and effective early intervention strategy that may enhance functional outcomes and reduce complications in patients with distal radius fractures.