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OBJECTIVE: To compare the efficacy of harmonic scalpel versus Milligan Morgan technique in patients undergoing haemorrhoidectomy. METHODOLOGY: The comparative study was conducted at the General Hospital, Lahore, Pakistan, from March to September 2019, and comprised patients undergoing haemorrhoidectomy who were randomised into haemorrhoidectomy group A and open haemorrhoidectomy group B which was exposed to the Milligan Morgan procedure. Data was collected through a predesigned questionnaire. Data was analysed using SPSS 25. RESULTS: Of the 60 patients, there were 30(50%) in group A; 17(56.7%) males and 13(43.3%) females with an overall mean age of 44.6±7.6 years. The remaining 30(50%) patients were in group B; 19(63.3%) males and 11(36.7%) females with an overall mean age of 43.8±8.2 years. In group A, mean operative time was 20.8±2.8 minutes, while it was 26.5±2.8 minutes in group B (p=0.001). In group A, mean convalescence period was 9.7±2.9 days, while it was 13.4±3.7 days in group B (p=0.001). Group A required less time for complete wound healing compared to group B (p<0.05). CONCLUSIONS: Harmonic scalpel haemorrhoidectomy was found to be an advantageous method compared to the Milligan Morgan technique in patients undergoing haemorrhoidectomy.