‹ Knowledge base
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Walk the evidence base by book and chapter — the raw source passages that ground Ask, Differential, and the rest.
- A randomized, double-blind, placebo-controlled, 12-week trial of vitamin D augmentation in major depressive disorder associated with vitamin D deficiency1 passage
- Actigraphic monitoring of sleep and circadian rest-activity rhythm in individuals with major depressive disorder or depressive symptoms: A meta-analysis1 passage
- Adjunctive ketamine and electroconvulsive therapy for major depressive disorder: A meta-analysis of randomized controlled trials1 passage
- Allopurinol augmentation in acute mania: A meta-analysis of placebo-controlled trials1 passage
- An app responding to behavior of people to promote mental wellbeing in anxious youth1 passage
- An exploratory randomized controlled trial of an AI-enabled mental health intervention for generalized anxiety1 passage
- An updated systematic review and meta-analysis of the predictive validity of the general anxiety disorder (GAD)-7 and GAD-2 in screening for anxiety disorders1 passage
- Assessment of the relationships between genetic determinants of thyroid functions and bipolar disorder: A mendelian randomization study1 passage
- Association between irritability and suicide-related outcomes across the life-course. Systematic review of both community and clinical studies1 passage
- Augmentation strategies for treatment resistant major depression: A systematic review and network meta-analysis1 passage
- Augmenting the unified protocol for transdiagnostic treatment of emotional disorders with transcranial direct current stimulation in individuals with generalized anxiety disorder and comorbid depression: A randomized controlled trial1 passage
- Causal effect of systemic lupus erythematosus on psychiatric disorders: A two-sample Mendelian randomization study1 passage
- Ceramides and depression: A systematic review1 passage
- Cognitive behavioral therapy for insomnia to treat major depressive disorder with comorbid insomnia: A systematic review and meta-analysis1 passage
- Cognitive outcomes from the randomised, active-controlled Ketamine for Adult Depression Study (KADS)1 passage
- Cognitive, behavioural or cognitive-behavioural self-help interventions for subclinical depression in older adults: A systematic review and meta-analysis1 passage
- Comorbid Cannabis Use Disorder with Major Depression and Generalized Anxiety Disorder: A Systematic Review with Meta-analysis of Nationally Representative Epidemiological Surveys1 passage
- Comparative efficacy of racemic ketamine and esketamine for depression: A systematic review and meta-analysis1 passage
- Comparing depression screening tools (CESD-10, EPDS, PHQ-9, and PHQ-2) for diagnostic performance and epidemiologic associations among postpartum Kenyan women: Implications for research and practice1 passage
- Consequence of child and adolescent depressive symptom trajectories for adult depressive disorders and symptoms: A systematic review & meta-analysis1 passage
- Cost-effectiveness of pramipexole in addition to mood stabilisers for patients with treatment-resistant bipolar depression: Economic evaluation of the PAX-BD randomised controlled trial1 passage
- Depression related cerebral pathology and its relationship with cognitive functioning: A systematic review1 passage
- Diet and depression: A systematic review of whole dietary interventions as treatment in patients with depression1 passage
- Digging deeper in the differential effects of inflammatory and psychosocial stressors in remitted depression: Effects on cognitive functioning1 passage
- Digital mental health interventions for the treatment of depression: A multiverse meta-analysis1 passage
- Dose effect of psilocybin on primary and secondary depression: a preliminary systematic review and meta-analysis1 passage
- Dropout from exercise randomized controlled trials among people with depression: A meta-analysis and meta regression1 passage
- Dysfunctional attitudes or extreme response style as predictors of depressive relapse and recurrence after mobile cognitive therapy for recurrent depression1 passage
- Effect of aripiprazole on promoting cognitive function and enhancing clinical efficacy in patients with first-episode depression on escitalopram: A randomized controlled trial1 passage
- Effect of intermittent theta burst stimulation on suicidal ideation and depressive symptoms in adolescent depression with suicide attempt: A randomized sham-controlled study1 passage
- Effect of photobiomodulation intervention for depressive symptoms: A systematic review and meta-analysis1 passage
- Effectiveness of cognitive rehabilitation in children and adolescents with ADHD: A review of EEG studies1 passage
- Effectiveness of mindfulness-based cognitive therapy against suicidal ideation in patients with depression: A systematic review and meta-analysis1 passage
- Effectiveness of mindfulness-based cognitive therapy for treating generalized anxiety disorder and the moderating influence of abuse during childhood: A randomized controlled trial1 passage
- Effects of eight weeks of aerobic exercise and vitamin D supplementation on psychiatric comorbidities in men with migraine and vitamin D insufficiency: A randomized controlled clinical trial1 passage
- Effects of exercise training on inflammatory, neurotrophic and immunological markers and neurotransmitters in people with depression: A systematic review and meta-analysis1 passage
- Efficacy and moderators of metacognitive training for depression in older adults (MCT-Silver): A randomized controlled trial1 passage
- Efficacy and safety of add-on dextromethorphan on irritability in children with ADHD treated with methylphenidate: A randomized double-blind controlled trial1 passage
- Efficacy and safety of repetitive transcranial magnetic stimulation combined with antidepressants in children and adolescents with depression: A systematic review and meta-analysis1 passage
- Efficacy and safety of transcranial magnetic stimulation in the treatment of children, adolescents and young adults with depression: A meta-analysis of randomized controlled trials1 passage
- Efficacy of a short-term physical exercise intervention on stress biomarkers and mental health in adolescents with ADHD: A randomized controlled trial1 passage
- Efficacy of adjunctive intermittent theta-burst stimulation on depressive and insomnia symptoms in elderly patients with depression and comorbid insomnia: A randomized, sham-controlled trial1 passage
- Efficacy of exercise combined with standard treatment for depression compared to standard treatment alone: A systematic review and meta-analysis of randomized controlled trials1 passage
- Efficacy of intravenous ketamine and intranasal esketamine with dose escalation for Major depression: A systematic review and meta-analysis1 passage
- Efficacy of low intensity interventions for geriatric depression and anxiety - A systematic review and meta-analysis1 passage
- Executive functioning in individuals with generalized anxiety disorder: A systematic review and meta-analysis1 passage
- Exercise as a treatment for depression: A meta-analysis1 passage
- Exercise improves cardiorespiratory fitness in people with depression: A meta-analysis of randomized control trials1 passage
- Fecal microbiota transplant on Escherichia-Shigella gut composition and its potential role in the treatment of generalized anxiety disorder: A systematic review1 passage
- Global burden of depression or depressive symptoms in children and adolescents: A systematic review and meta-analysis1 passage
- Gut microbiota and major depressive disorder: A systematic review and meta-analysis1 passage
- Heart rate variability in generalized anxiety disorder, major depressive disorder and panic disorder: A network meta-analysis and systematic review1 passage
- Information technology-based versus face-to-face cognitive-behavioural therapy for anxiety and depression: A systematic review and meta-analysis1 passage
- Intermittent escitalopram treatment and reactive aggression in women with premenstrual irritability and anger: A crossover study1 passage
- Interpersonal sensitivity and response to selective serotonin reuptake inhibitors in patients with acute major depressive disorder1 passage
- Intranasal esketamine effectively treats treatment-resistant depression in adults regardless of baseline irritability1 passage
- Intranasal oxytocin as an adjunct treatment among patients with severe major depression with and without comorbid borderline personality disorder1 passage
- Irritability as an independent predictor of concurrent and future suicidal ideation in adults with stimulant use disorder: Findings from the STRIDE study1 passage
- Meaningful Change in Depression Symptoms Assessed with the Patient Health Questionnaire (PHQ-9) and Montgomery-Åsberg Depression Rating Scale (MADRS) Among Patients with Treatment Resistant Depression in Two, Randomized, Double-blind, Active-controlled Trials of Esketamine Nasal Spray Combined With a New Oral Antidepressant1 passage
- Meta-analysis of prospective longitudinal cohort studies on the impact of childhood traumas on anxiety disorders1 passage
- Mindfulness interventions and quality of life in anxiety-related disorders: A systematic review and meta-analysis1 passage
- Multimorbidity and depression: A systematic review and meta-analysis1 passage
- Non-directive supportive therapy for depression: A meta-analytic review1 passage
- Omega-3 polyunsaturated fatty acids supplementation improves memory in first-diagnosed, drug-naïve patients with depression: Secondary analysis of data from a randomized controlled trial1 passage
- Prevention bends adolescent internalizing trajectories: Within-person changes from pre- to post-prevention1 passage
- Process of change and efficacy of acceptance and commitment therapy (ACT) for anxiety and depression symptoms in adolescents: A meta-analysis of randomized controlled trials1 passage
- Psychedelic therapy for depressive symptoms: A systematic review and meta-analysis1 passage
- Psychological interventions for social anxiety disorder in children and adolescents: A systematic review and network meta-analysis1 passage
- Psychosocial interventions on perinatal depression in China: A systematic review and meta-analysis1 passage
- Psychotherapies for social anxiety disorder in adults: A systematic review and Bayesian network meta-analysis1 passage
- Real-time EEG-triggered transcranial magnetic stimulation combined with group therapy for adolescents with depression and self-harm behavior: A randomized controlled trial1 passage
- Recovery from recurrent depression: Randomized controlled trial of the efficacy of mindfulness-based compassionate living compared with treatment-as-usual on depressive symptoms and its consolidation at longer term follow-up1 passage
- Religious-based interventions for depression: A systematic review and meta-analysis of experimental studies1 passage
- Repetitive transcranial magnetic stimulation frequency effects on suicidal ideation in adolescents with major depressive disorder1 passage
- Resistance exercise training compared to a low-intensity sham for depressive symptoms in young women with analogue generalized anxiety disorder: A randomized controlled trial1 passage
- Shared genetic influences between depression and conduct disorder in children and adolescents: A systematic review1 passage
- Systematic review and meta-analysis of randomised controlled trials for evaluating the effectiveness of virtual reality therapy for social anxiety disorder1 passage
- Temperament correlates in adult ADHD: A systematic review(★★)1 passage
- Test accuracy of the Overall Anxiety Severity and Impairment Scale (OASIS) for screening anxiety in adults - systematic review and multiple thresholds meta-analysis1 passage
- The Therapeutic Effect of Aromatherapy on Insomnia: a Meta-Analysis1 passage
- The effects of statin monotherapy on depressive symptoms: A systematic review and meta-analysis1 passage
- The kynurenine pathway in major depressive disorder under different disease states: A systematic review and meta-analysis1 passage
- The predictive value of insomnia for the treatment outcome of pharmacotherapy, psychotherapy, and combined therapy in major depressive disorder: A mega-analysis of five randomised clinical trials1 passage
- The relationship between interoception and anxiety, stress and obsessive-compulsive disorders in adult clinical populations - A systematic review and narrative synthesis1 passage
- Transcranial direct current stimulation for the treatment of generalized anxiety disorder: A randomized clinical trial1 passage
- Treating a broader range of depressed adolescents with combined therapy1 passage
- Vagally-mediated heart rate variability and depression in children and adolescents - A meta-analytic update1 passage
- What are the effects of preventative interventions on major depressive disorder (MDD) in young adults? A systematic review and meta-analysis of randomized controlled trials1 passage
- Who engages? Machine learning insights into digital mindfulness-based intervention for generalized anxiety disorder1 passage