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Unlabelled: This guideline covers assessing for, and managing, blood transfusions in adults, young people and children aged 1 year and over. It covers the general principles of blood transfusion, but does not make recommendations relating to specific conditions. This guideline does not cover blood transfusions, or use of tranexamic acid for surgery, during pregnancy and labour. For more information on what the guideline does and does not cover, see the section on inclusions and exclusions. Some people have religious beliefs that do not allow the transfusion of blood. Specific issues relating to these people have been addressed when reviewing the evidence and writing the recommendations. For guidance on blood transfusions and anticoagulant reversal for people with acute upper gastrointestinal bleeding, see the section on resuscitation and initial management in NICE's guideline on acute upper gastrointestinal bleeding in over 16s. Who is it for?: Healthcare professionals who assess for and manage blood transfusions and their alternatives. Commissioners and providers of transfusion services. People aged 1 year and over who may need a blood transfusion, their families and carers.