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Table of Contents Headache and Facial Pain Seizures and Epilepsy in Specific Populations. ....... 24 Approach to the Patient with Headache.............. 1 QldGE AGUNG sos 9 ¢ Geax we «cs ogee xe d¥a038 Be ees es 24 SCCONGALY HEAGACKE z pss cco secna wen sars aon amres mB RY MES 2 Women with Epilepsy....................0005 24 Thunderclap Headache. .... i. s..2 e062 actapes ane ave 2 Statlis EpUepuCus! +s <cn0casdeiadesres iwesnnowe ane 24 Idiopathic Intracranial Hypertension ............ 4 Convulsive Status EpilepueusS ...24.s:acseaswva 2d Headaches from Intracranial Hypotension ....... 5 Nonconvulsive Status Epilepticus .............. 26

Thunderclap Headache. .... i. s..2 e062 actapes ane ave 2 Statlis EpUepuCus! +s <cn0casdeiadesres iwesnnowe ane 24 Idiopathic Intracranial Hypertension ............ 4 Convulsive Status EpilepueusS ...24.s:acseaswva 2d Headaches from Intracranial Hypotension ....... 5 Nonconvulsive Status Epilepticus .............. 26 Trigeminal Neuralgia....... 0.0.0.0... eee eee eee 5 Medication-Induced Headache ................. 6 Stroke Primary Headache «csn.s <sicem saw some ceed sant ameein ag 6 DetmiGOnol SHOKEG:« »e< ses em ese s ene ems we Bes Ess 26 MiStAIHG\.. « ss usa vet be rais am Eee Ses sed me Es 6 Diagnosis of Stroke... 0... eee 260 Tension-Type Headache .............-..00-008- 9 Stroke SUDtyPES. 20: a6 sc scinss aue seis eas 8 ld wig a enw eas 29 Trigeminal Autonomic Cephalalgias............ 10 Transient Ischemic Attack ..................05 29 ISCHEMIC SEIORC +s sm smaswee aeseeoes noes ace meanW Head Injury Hemorrhagic Stroke ...............0002...02-.32 Trauniiatie Brain. INjuny.22ss.¢00s exces awceewae nce i In-Hospital Stroke Considerations..............33 Mild Traumatic Brain Injury .................. 11 ACHE SIFOKE [NGM DY scans. saci goth sepwrsseeravec Od Severe Traumatic Brain Injury................. 12 Ischemic Stroke Treatment «<sesa<a% coc seen BO Epidural and Subdural Hematoma............. 12 Antiplatelet Therapy, Anticoagulation, Head Injury in Special Populations................. 13 and Medical Management ....................33 ACCES: Fev sarge esta m 5 aOR: Ss GEG ya FI Eee Bas i Hemorrhagic Stroke Treatment................ 3D

Trigeminal Neuralgia....... 0.0.0.0... eee eee eee 5 Medication-Induced Headache ................. 6 Stroke Primary Headache «csn.s <sicem saw some ceed sant ameein ag 6 DetmiGOnol SHOKEG:« »e< ses em ese s ene ems we Bes Ess 26 MiStAIHG\.. « ss usa vet be rais am Eee Ses sed me Es 6 Diagnosis of Stroke... 0... eee 260 Tension-Type Headache .............-..00-008- 9 Stroke SUDtyPES. 20: a6 sc scinss aue seis eas 8 ld wig a enw eas 29 Trigeminal Autonomic Cephalalgias............ 10 Transient Ischemic Attack ..................05 29 ISCHEMIC SEIORC +s sm smaswee aeseeoes noes ace meanW Head Injury Hemorrhagic Stroke ...............0002...02-.32 Trauniiatie Brain. INjuny.22ss.¢00s exces awceewae nce i In-Hospital Stroke Considerations..............33 Mild Traumatic Brain Injury .................. 11 ACHE SIFOKE [NGM DY scans. saci goth sepwrsseeravec Od Severe Traumatic Brain Injury................. 12 Ischemic Stroke Treatment «<sesa<a% coc seen BO Epidural and Subdural Hematoma............. 12 Antiplatelet Therapy, Anticoagulation, Head Injury in Special Populations................. 13 and Medical Management ....................33 ACCES: Fev sarge esta m 5 aOR: Ss GEG ya FI Eee Bas i Hemorrhagic Stroke Treatment................ 3D Military Personnel, «. « ...0% 252 Peat Wes wv ace i aba 14 SUHGKE PFEVENHON. ¢ a:5 spe 5 weaves ees dees 8 ee a wis ea was 36

Trigeminal Neuralgia....... 0.0.0.0... eee eee eee 5 Medication-Induced Headache ................. 6 Stroke Primary Headache «csn.s <sicem saw some ceed sant ameein ag 6 DetmiGOnol SHOKEG:« »e< ses em ese s ene ems we Bes Ess 26 MiStAIHG\.. « ss usa vet be rais am Eee Ses sed me Es 6 Diagnosis of Stroke... 0... eee 260 Tension-Type Headache .............-..00-008- 9 Stroke SUDtyPES. 20: a6 sc scinss aue seis eas 8 ld wig a enw eas 29 Trigeminal Autonomic Cephalalgias............ 10 Transient Ischemic Attack ..................05 29 ISCHEMIC SEIORC +s sm smaswee aeseeoes noes ace meanW Head Injury Hemorrhagic Stroke ...............0002...02-.32 Trauniiatie Brain. INjuny.22ss.¢00s exces awceewae nce i In-Hospital Stroke Considerations..............33 Mild Traumatic Brain Injury .................. 11 ACHE SIFOKE [NGM DY scans. saci goth sepwrsseeravec Od Severe Traumatic Brain Injury................. 12 Ischemic Stroke Treatment «<sesa<a% coc seen BO Epidural and Subdural Hematoma............. 12 Antiplatelet Therapy, Anticoagulation, Head Injury in Special Populations................. 13 and Medical Management ....................33 ACCES: Fev sarge esta m 5 aOR: Ss GEG ya FI Eee Bas i Hemorrhagic Stroke Treatment................ 3D Military Personnel, «. « ...0% 252 Peat Wes wv ace i aba 14 SUHGKE PFEVENHON. ¢ a:5 spe 5 weaves ees dees 8 ee a wis ea was 36 Oldéf Patients) o.2s<scca0s uses ease eew saws aes 14 Primary Prevention..................00..0008 36 Patients Receiving Anticoagulation............. 14 Secondary Prevention........................ 37 Standardized Discharge Orders....................38 Seizures and Epilepsy Prognosis and Recovery vaaccwexceayatesadanwnm ann OO

Oldéf Patients) o.2s<scca0s uses ease eew saws aes 14 Primary Prevention..................00..0008 36 Patients Receiving Anticoagulation............. 14 Secondary Prevention........................ 37 Standardized Discharge Orders....................38 Seizures and Epilepsy Prognosis and Recovery vaaccwexceayatesadanwnm ann OO Clinical Presentation of Seizures...............00-- 14 Neurologic Complications ....................38 FOCALSEIAUTES: 22% sereacem eee sees mess peeae eat 14 Medical Complications and Stroke Generalized SeiZUTES. 0. ce cae oa saws ese: 14 EDIEpSY SYNGLOMIES a v5.42 eesm earqem posh es wade deme 15 Long-Term Prognosis and Recovery ............! 39 Focal Epilepsies .......... 0... c eee eee ee eee 15

Clinical Presentation of Seizures...............00-- 14 Neurologic Complications ....................38 FOCALSEIAUTES: 22% sereacem eee sees mess peeae eat 14 Medical Complications and Stroke Generalized SeiZUTES. 0. ce cae oa saws ese: 14 EDIEpSY SYNGLOMIES a v5.42 eesm earqem posh es wade deme 15 Long-Term Prognosis and Recovery ............! 39 Focal Epilepsies .......... 0... c eee eee ee eee 15 Idiopathic (Genetic) Generalized Epilepsies...... 17 Cognitive Impairment Diagnostic Evaluation of Seizures and Epilepsy....... ayy DEMO og s w.cie eee dia iouace mgmenieons seep aged Seba OO Initial Approach to the Patient with a General Approach to the Patient with INISUSEIZUTEs ssa mesanceerersecoweneamenmeees 17 COPHIIVE IINPaIIMent. 2asseccrsaqes4sacs new n anne Differential Diagnosis of Seizures .............. 18 DEMHUMN .ue0<. Beat sitekrans emi nene new oeeses Al Diagnostic Evaluation..............00 cece wees 18 TECAMMEN cia e i cnrnare roe oem HEE SEH RET OE 41 Provoked, Unprovoked, and Triggered Mild Cognitive Impairment ....................... 4] SeIZULES 2 se0sserw teers e es rmeswarmsmermese: 20 TRCAMMIONG, . 4.00023 Seems ware bwies eos saws caw s 42 Treatment of Epilepsy. .......... 0.0.0 cee eee eens Pit PREVENHON, «5:24 © caw cares mew gmon ew eee wie am eewE 42 Antiepileptic Drug Therapy ................... 21 DCWIGIMAS x 5 oxd WINS oh ona Phe» wes ore 5 AEB EGE EE GEE Hs 42 Counseling and Lifestyle Adjustments .......... 23 Dementias without Early Motor Signs .......... 43 Comorbidities and Complications of Epilepsy........ 23 Dementias with Early Motor Signs ............. 47 Sudden Unexpected Death in Epilepsy Patients . . 23 Treatment Approach to Neurobehavioral Drug-Resistant Epilepsy and Epilepsy Surgery .. . 23 Symptoms of Dementia ...................6.4550

Movement Disorders Neuromuscular Disorders Overview of Movement Disorders...............00 50 OVERVIEW as oy casagunt SHLAA Eat oe ee ary WEBNS 4 ort 75 Hypokinetic Movement Disorders. ................. 50 Peripheral Neuropathies.................eeeeeeees 75 ParkiSOn-DISCASE «a0 rai Fie Get ores eee RS ® ane 51 Classification, Findings, and Diagnosis ......... 75 Parkinson-Plus Syndromes ................--- 56 Mononeuropathies .<...420355e240s seces ces ax 77 Drug-Induced Parkinsonism.................. 56 Polyneuropathies..............-... eee eee eee 80 Hyperkinetic Movement Disorders................. 56 Amyotrophic Lateral Sclerosis..................00. 83 BSSENUAL TREMIOE, once ton bd BESS RE eee 56 Neuromuscular Junction Disorders ................ 84 DVS (OTAL cc. cin. nieiens ais od SHINER SSW SRE Gas Aes 59 Myasthenia Graviscacs scs20a0 temersaweneemeer 84 Choreiform Disorders and Huntington Disease. . . 59 Lambert-Eaton Myasthenic Syndrome.......... 84 MYCCIONUS|: cn:2n sseeseransws seem seea me eces 60 MYOPatbies c's s.05 ge se gaPe ieee Secs Sea eorH ae exer aware we 85 Tic Disorders and Tourette Syndrome........... 60 OVERVICW! 255d. abaad Ge oh ogg a eae aws me ooh Tees 85 Restless Legs Syndrome and Sleep-Related Inflammatory Myopathy. .... i c2.c6..:acseresem: 86 Movement: Disorder: 2: 5250 ¢ses wesw ssge metas 61 Endocrine-Related Myopathy ................. 86 Other Drug-Induced Movements .............. 61 TOXIC. MYOPathay, i x sca s sees aie ns Seetls nb anes ene oie ate 86

Hyperkinetic Movement Disorders................. 56 Amyotrophic Lateral Sclerosis..................00. 83 BSSENUAL TREMIOE, once ton bd BESS RE eee 56 Neuromuscular Junction Disorders ................ 84 DVS (OTAL cc. cin. nieiens ais od SHINER SSW SRE Gas Aes 59 Myasthenia Graviscacs scs20a0 temersaweneemeer 84 Choreiform Disorders and Huntington Disease. . . 59 Lambert-Eaton Myasthenic Syndrome.......... 84 MYCCIONUS|: cn:2n sseeseransws seem seea me eces 60 MYOPatbies c's s.05 ge se gaPe ieee Secs Sea eorH ae exer aware we 85 Tic Disorders and Tourette Syndrome........... 60 OVERVICW! 255d. abaad Ge oh ogg a eae aws me ooh Tees 85 Restless Legs Syndrome and Sleep-Related Inflammatory Myopathy. .... i c2.c6..:acseresem: 86 Movement: Disorder: 2: 5250 ¢ses wesw ssge metas 61 Endocrine-Related Myopathy ................. 86 Other Drug-Induced Movements .............. 61 TOXIC. MYOPathay, i x sca s sees aie ns Seetls nb anes ene oie ate 86 Inherited Myopathies ..................000005 86 Multiple Sclerosis Presenting Signs and Symptoms..................-- 62 Neuro-oncology Diagnosis of Multiple Sclerosis .................... 63 Approach to Intracranial Tumors .................. 87 Diagnostic Criteria and Testing ................ 63 Metastatic Brain Tumors, .. .«22s.2ses2eaersnseesewes 87 Differential Diagnosis of Multiple Sclerosis ...... 64 Primary Central Nervous System Tumors ........... 87 Treatment’ OE Multiple SElErOSISss s<20920026o80aane sae 66 MENINGIGMIAS s, zgins aaninanniniin sais Reriatnecae cnc Dat SRS 87 Lifestyle Modifications and General Health Care. . 66 Glioblastoma Multiformeé. osss52sencnaeersxees 88 Treatment of Acute Exacerbations ............. 67 Primary Central Nervous System Disease-Modifying Therapies.................. 67 Lys PHONE 35 site ea tes inet nays HOT Rann sere oh DOR 89 Symptomatic Management ................... 70 Medical Management of Complications of Central Nervous System Tumors................04. 89

Inherited Myopathies ..................000005 86 Multiple Sclerosis Presenting Signs and Symptoms..................-- 62 Neuro-oncology Diagnosis of Multiple Sclerosis .................... 63 Approach to Intracranial Tumors .................. 87 Diagnostic Criteria and Testing ................ 63 Metastatic Brain Tumors, .. .«22s.2ses2eaersnseesewes 87 Differential Diagnosis of Multiple Sclerosis ...... 64 Primary Central Nervous System Tumors ........... 87 Treatment’ OE Multiple SElErOSISss s<20920026o80aane sae 66 MENINGIGMIAS s, zgins aaninanniniin sais Reriatnecae cnc Dat SRS 87 Lifestyle Modifications and General Health Care. . 66 Glioblastoma Multiformeé. osss52sencnaeersxees 88 Treatment of Acute Exacerbations ............. 67 Primary Central Nervous System Disease-Modifying Therapies.................. 67 Lys PHONE 35 site ea tes inet nays HOT Rann sere oh DOR 89 Symptomatic Management ................... 70 Medical Management of Complications of Central Nervous System Tumors................04. 89 Disorders of the Spinal Cord SEIZUIGS ccs waswiv eras med © Pome § See a ewes Benes my aes 89 Edema and Herniation.................00e eee 89 Presenting Symptoms and Signs of Myelopathy ...... 71 Venous Thromboembolism ................... 89 Compressive Myelopathy’ <<c0+sweecemeaveses aaa 72 Clinical Presentation.....................005. 72. Paraneoplastic/Autoimmune Neurologic Syndromes ..............00 cee eee eaee 90 DISBHOSIS) .« cscs cae etEss eee eee 72 TICAHENC: «.conneqeee we mamedenee du we seams 72

Disorders of the Spinal Cord SEIZUIGS ccs waswiv eras med © Pome § See a ewes Benes my aes 89 Edema and Herniation.................00e eee 89 Presenting Symptoms and Signs of Myelopathy ...... 71 Venous Thromboembolism ................... 89 Compressive Myelopathy’ <<c0+sweecemeaveses aaa 72 Clinical Presentation.....................005. 72. Paraneoplastic/Autoimmune Neurologic Syndromes ..............00 cee eee eaee 90 DISBHOSIS) .« cscs cae etEss eee eee 72 TICAHENC: «.conneqeee we mamedenee du we seams 72 Noncompressive Myelopathy................000005 73 Bibliography .................. 0.0... cece eee 91 Idiopathic Transverse Myelitis................. 73 Subacute Combined Degeneration ............. 74 Self-Assessment Test........................00005 95 Vascular Disorders ........ 0.0. c cece eee ee 74 GEnetC: DISOTUEIS: 0a .snive as e-2ee eam rwares 75 Es ccsseweu repariecapeserensaapecamiee erat 165