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Insights from Modern Physics. The practice of anesthesiology is both an art and a science. Despite the increasing emphasis on using scientific evidence to inform clinical decisions, the "art" of considering the contextual intricacies surrounding those decisions is equally important. This article borrows concepts from quantum mechanics and discuss how anesthesiology, too, is practiced and researched in complex systems with intrinsic uncertainty and unpredictability. The authors encourage the reader to reflect on the influence of contextual factors when appraising and applying scientific evidence to their own practice.