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How strategic engagement with programs drives neurosurgery match success. OBJECTIVE: As the neurosurgery residency application process grows increasingly reliant on strategy, applicants must weigh relationship-building efforts against academic metrics. This study evaluated how program-specific engagement influences match outcomes and how its importance has evolved following the adoption of United States Medical Licensing Examination (USMLE) Step 1 pass/fail (P/F) grading and program signaling. METHODS: The authors analyzed survey responses from 465 US MD applicants to neurosurgery programs, corresponding to 2637 applications submitted between 2022 and 2025 using the Texas Seeking Transparency in Applications to Residency (TexasSTAR) database. Multivariable logistic regression models evaluated the association between relationship-building variables (away rotation, program signaling, geographic connection, and regional preference) with match success. Stratified models examined interactions with USMLE Step 2 clinical knowledge (CK) score and publication count. One-way ANOVA assessed temporal changes in predictor importance. A random forest machine learning model was developed to identify dominant factors in obtaining an interview. RESULTS: Away rotation was the strongest independent predictor of match success (adjusted OR [aOR] 8.48, p < 0.001) and interview offer (aOR 23.6, p < 0.001), followed by program signaling (aOR 2.17, p < 0.001; interview aOR 2.15, p < 0.001), and geographic connection (aOR 3.47, p < 0.001). Preferred region was not significantly associated with either outcome. Stratified analyses revealed that relationship variables (away rotation, geographic connection, program signaling) had stronger predictive value for applicants with lower academic metrics (e.g., Step 2 CK score < 244, < 5 publications). Following Step 1 P/F grading transition and program signaling in 2022, applicants submitted fewer applications (p < 0.001) and attended fewer interviews (p = 0.001), while reliance on program-specific engagement increased. Step 2 CK score and number of publications declined in predictive power after 2022. Random forest modeling (89% accuracy) identified away rotation, program signaling, geographic connection, and Step 2 CK score as the strongest interview predictors. CONCLUSIONS: Program-specific engagement strategies are the strongest predictors of obtaining an interview in neurosurgery residency matching. Their growing importance after the transition to USMLE Step 1 P/F grading suggests applicants gain more from targeted connections than broad application volume. Declining application and interview count further reflect a trend toward more strategic engagement.