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The foramen of Hyrtl: a neuroanatomical legacy. Prominent 19th-century anatomist Josef Hyrtl (1810-1894) made contributions to anatomy that continue to influence contemporary medical practice. Highlighting his discovery of the foramen of Hyrtl and its relevance in neuroradiology and neurosurgery, the authors explore Hyrtl's life, career, and lasting impact. Dr. Hyrtl transformed anatomical education through innovative teaching strategies, emphasizing practical dissection and observation. His comprehensive research into comparative anatomy, the vascular system of the head and neck, and ear anatomy advanced our understanding across various medical fields. One focus of Hyrtl was a landmark feature in the superolateral bony orbit, where a small arterial connection exists between the middle meningeal artery of the external carotid artery and the ophthalmic artery. Attention to the small, superior orbital bony aperture-the foramen of Hyrtl, which contains this collateral branch-is necessary for the safety of modern interventional techniques to avoid blindness and stroke. The legacy of Hyrtl underscores the importance of fundamental anatomical knowledge in medical advancement, despite a career marked by both controversy and acclaim. This review highlights the interconnectedness of anatomical observations throughout history and their ongoing value in enhancing medical knowledge and improving patient care by examining Hyrtl's contributions in both historical and contemporary contexts.