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Childhood Vaccine Hesitancy. Vaccine hesitancy exists along a spectrum; most parents with hesitancy are motivated to protect their children but are often concerned about safety. Routine childhood vaccines recommended by the American Academy of Pediatrics have substantially reduced the incidence of disease and maintain a strong safety record. Clinicians are the most trusted source of vaccine information, and clear, confident recommendations are closely linked to higher uptake. Presumptive communication approaches are more effective than open-ended approaches, especially when paired with respectful dialogue. Empathy-driven, patient-centered strategies, including motivational interviewing, help address concerns, counter misinformation, and build trust while preserving relationships that may encourage future vaccination decisions.