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The large intestine is the portion of the digestive tract where water is absorbed from indigestible material (see Image. Large Intestine). This section of the gut includes the cecum, appendix, entire colon, rectum, and anal canal. The large intestine begins at the terminal ileum with the cecum. Unlike the small intestine, the large bowel is shorter but has a much larger lumen. This segment is further distinguished from the small intestine by the presence of omental appendices, haustra, and teniae coli.[1][2][3] The omental appendices are small pouches of peritoneum filled with fat. The haustra are small pouches or sacculations that give the large intestine its segmented appearance. The teniae coli are 3 longitudinal bands of smooth muscle on the outer wall of the colon. Disorders such as colorectal cancer, inflammatory bowel disease, and diverticulosis can impact large bowel function. Surgical interventions, such as colectomy, hemicolectomy, and proctectomy, are performed for colorectal cancer, severe inflammatory bowel disease, or bowel obstruction. A thorough understanding of the anatomy and function of this part of the digestive tract will help clinicians diagnose and manage gastrointestinal disorders, optimize surgical interventions, and improve patient outcomes.