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The sympathetic nervous system is comprised exclusively of efferent neurons and divides into the left and right sympathetic chains.[1] Each sympathetic chain extends from the skull base to the coccyx paravertebrally, carrying preganglionic fibers from the spinal cord that synapse in an adjacent ganglion, from which ascending and descending postganglionic fibers head toward viscera.[2][3] The ganglia adjacent to the sympathetic chain are known as sympathetic chain ganglia, comprising the cervical, thoracic, lumbar, and sacral ganglia.[4] This topic discusses the defining features of the cervical sympathetic chain and its associated ganglia.