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The arteries of the forearm are muscular arteries that originate from the brachial artery at its bifurcation into the ulnar and radial arteries in the cubital fossa. The division occurs anterior to the radius and ulna at approximately the level of the radial neck or radial tuberosity.[1][2] Soon after the bifurcation of the brachial artery, branches from the ulnar and radial arteries travel superiorly to anastomose with branches of the brachial artery around the elbow joint. These branches include the radial recurrent artery and the anterior and posterior ulnar recurrent arteries. Distal to the origins of these branches, the common interosseous artery originates from the ulnar artery and bifurcates into the anterior and posterior interosseous arteries. The recurrent interosseous artery branches off the posterior interosseous artery to travel proximally and anastomose with a branch of the deep brachial artery. The ulnar, radial, and anterior and posterior interosseous arteries course down the forearm. They branch into dorsal and palmar carpal arteries that supply the wrist and deep and superficial palmar branches that supply the hand. The arteries of the forearm supply the muscles and nerves of the forearm that control the hands. Anatomists have described several variants of the arterial anatomy. This activity will discuss in detail the anatomic details of the arteries of the forearm and their clinical significance.