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The skin is the body's largest and primary protective organ, covering its entire external surface and serving as a first-order physical barrier against the environment. Its functions include temperature regulation and protection against ultraviolet light, trauma, pathogens, microorganisms, and toxins. The skin also plays a role in immunologic surveillance, sensory perception, the control of insensible fluid loss, and general homeostasis. The skin is also highly adaptive, with varying thicknesses and specialized functions across different body sites. This topic discusses the anatomy of the skin, including its structure, function, embryology, blood, lymphatic, and nerve supply, surgical, and clinical significance.[1][2]