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introductionstatpearls· Introduction· item NBK553218

The left atrial appendage (LAA) is a unique structure within the pericardium, close to the free wall of the left ventricle. It has unique developmental, structural, and physiological characteristics that separate it from the left atrium proper.[1] In normal cardiac physiology, the LAA plays an essential role in regulating intravascular volume by releasing natriuretic peptides in response to hemodynamic changes. The LAA also plays a vital role in the pathogenesis of transient ischemic attack (TIA) and stroke in patients with atrial fibrillation (AF).[2]