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The superior vena cava (SVC) is a large, significant vein responsible for returning deoxygenated blood collected from the body to the right atrium. It is present within the superior and middle mediastinum. The superior vena cava handles the venous return of blood from structures located superior to the diaphragm. In contrast, its counterpart, the inferior vena cava, handles venous return from the portion of the body inferior to the diaphragm. The impedance of flow in the superior vena cava by thrombosis or external compression can cause hemodynamic compromise depending on the severity and acuity of the obstruction.[1]