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Anastrozole is a medication used in the management and treatment of breast cancer. It is in the aromatase inhibitors class of drugs. This activity describes the indications, action, and contraindications for anastrozole as a valuable agent in managing advanced hormone-receptive breast cancer. This activity will highlight the mechanism of action, adverse event profile, and other key factors (e.g., off-label uses, dosing, pharmacodynamics, pharmacokinetics, monitoring, relevant interactions) pertinent for members of the healthcare team in the management of patients with breast cancer and related conditions. Objectives: Describe the mechanism of action of aromatase inhibitors. Summarize the potential adverse reactions and contraindications of aromatase inhibitor use. Review the indicated uses for aromatase inhibitors in current medical practice. Outline the importance of improving care coordination amongst interprofessional team members to improve health care outcomes for patients affected by breast cancer and other conditions. Access free multiple choice questions on this topic.

Clinical trials have shown aromatase inhibitors were well tolerated, even at high doses.[27] There is no established dose of aromatase inhibitors considered life-threatening. There is no specific treatment for the overdose of this class of medications. Standard treatment of care, such as frequent vital sign checks, induced emesis, and management of symptoms, is recommended.

Interprofessional communication between healthcare teams is essential, especially in the management of cancer patients. Every professional has a vital role to play. Oncologists should select the treatment regimen based on the guidelines after thoroughly assessing the patient factors. For example, in hormone receptor-negative breast cancer or premenopausal patients with breast cancer, aromatase inhibitors may not be appropriate. Clinicians and nurses should be concerned enough about the adverse effects of long-term therapy with aromatase inhibitors, especially osteoporosis and hyperlipidemia. Pharmacists should evaluate the patient's medication history to prevent any drug interactions, especially with tamoxifen and warfarin. Nursing will provide patient counseling on the medication, answer patient questions, and serve as a contact point for patients and other interprofessional team members. Case management should include counseling regarding improving bone health and early initiation of bisphosphonates in the case of osteopenia. Utilizing these interprofessional strategies when using aromatase inhibitor therapy will lead to improved therapeutic patient results with fewer adverse events. [Level 5]