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Atrial natriuretic peptide (ANP) is a hormone secreted from the right atrium in response to atrial stretch from hypervolemia as well as in response to hypertension. Since its discovery in the early 1980s, there have subsequent discoveries of other natriuretic peptides, including brain or B-type natriuretic peptide (BNP) and C-type natriuretic peptide (CNP). ANP and BNP are predominately produced by cardiomyocytes, while CNP is found more in the central nervous system and peripheral tissues.[1] ANP and BNP have demonstrated properties leading to vasodilation, increase in natriuresis, diuresis, and antifibrotic and antihypertrophic effects within the heart.[1]
As discussed above, there continue to be many new discoveries with regards to atrial natriuretic peptide. We have discovered its effects on the vasculature, on the kidney, and lipolysis, among others. Each of these has a wide range of impacts on various pathologies, from hypertension to heart failure to even metabolic syndrome. In addition to continued studies into ANP, an interdisciplinary approach is also necessary to help tackle these disorders. From nurses checking vitals and drawing labs to pharmacists helping to dose future therapeutic regimens to physicians understanding the physiology behind ANP, it will require a team effort.