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This activity explores benzoyl peroxide, an over-the-counter topical medication that is FDA-approved for addressing acne vulgaris. The educational content delves into its bactericidal properties, specifically targeting Cutibacterium acnes within the skin and hair follicles. This activity equips healthcare professionals with essential knowledge for effective utilization in clinical settings by focusing on indications, mechanisms of action, and safe administration practices. Critical components of this program include a thorough examination of adverse drug reactions, contraindications, drug-drug interactions, clinical toxicology, and the necessity of monitoring various physiological aspects during benzoyl peroxide use. The curriculum underscores the significance of understanding intricate pharmacology to enable tailored treatment plans aligned with individual patient needs. Prioritizing patient safety becomes paramount, particularly considering the distinctive characteristics of the targeted patient population. Through an evidence-based approach, this educational initiative empowers healthcare professionals to make informed decisions, keeping them updated on the latest guidelines and recommendations and facilitating the optimal integration of benzoyl peroxide into treatment regimens, ultimately enhancing outcomes for patients grappling with acne vulgaris. Objectives: Identify the indications for benzoyl peroxide use. Evaluate the mechanism of action of benzoyl peroxide. Identify the most common adverse effects associated with benzoyl peroxide use. Implement effective collaboration and communication among interprofessional team members to improve outcomes and treatment efficacy for patients who might benefit from benzoyl peroxide treatment. Access free multiple choice questions on this topic.

Topical benzoyl peroxide should not be taken by mouth; indications are strictly limited to topical use. In case of ingestion, patients should call 911, contact the poison control center (1-800-222-1222), or report to the nearest emergency department. There are no known antidotes for this medication.

The most common medications prescribed for acne vulgaris by clinicians include benzoyl peroxide, retinoids, and topical/oral antibiotics. Rosacea and refractory cases of acne vulgaris may require consultation with a dermatologist. Pharmacists should educate patients about adverse drug reactions. Nurses should explain the importance of compliance. Despite their efficacy in treating mild-to-moderate acne vulgaris, studies have shown that combining antibiotics or retinoids with benzoyl peroxide is more productive than using either medication alone. The combination is believed to be synergistic and has also been shown to prevent the development of antibiotic resistance.[2][15] However, in a survey of patients with an indication for benzoyl peroxide as an additional acne treatment, only 30% of the patients obtained the benzoyl peroxide product.[28] Therefore, to improve patient compliance and treatment efficacy, healthcare providers should seek to prescribe combination products that would result in simpler skincare regimens and greater patient adherence. The initial disadvantage of combination products is their increased cost and need to be refrigerated to prevent degradation.[14] Although refrigeration is encouraged, cost reduction is possible through the utilization of specialty compounding pharmacies. An interprofessional team approach between clinicians (MDs, DOs, NPs, PAs), pharmacists, dermatologists, and nurses is necessary to optimize patient outcomes with benzoyl peroxide.