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introductionstatpearls· Introduction· item NBK576418

Autoimmunity refers to an aberration in the body's normal development that causes the immune system to mount an attack against its cells.[1] The etiology behind autoimmune diseases is multifactorial, with genetic, hormonal, and environmental factors all playing a role. This topic reviews the fundamentals of the antigen self-tolerance process, cellular and molecular processes contributing to autoimmunity, diagnostic indicators, and key diseases.