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The brachioradialis reflex is a deep tendon reflex mediated by C5–C6 and transmitted through the radial nerve. Elicited by tapping the tendon near the radial styloid, the normal response produces elbow flexion with slight forearm supination. This reflex plays an important role in localizing neurologic lesions by helping to differentiate upper from lower motor neuron pathology and to distinguish cervical radiculopathy from peripheral nerve disorders. Abnormal findings such as diminished, absent, asymmetric, or pathologically brisk responses may indicate underlying neurologic disease, like cervical myelopathy, nerve root compression, or radial neuropathy. When interpreted alongside other reflexes and neurologic findings, the brachioradialis reflex provides valuable diagnostic insight and may serve as an early indicator of spinal cord pathology. Effective patient-centered care related to brachioradialis reflex assessment relies on coordinated interprofessional collaboration. Physicians and advanced practitioners must demonstrate strong neurologic examination skills, accurately elicit reflexes, recognize abnormal patterns, and integrate findings into clinical decision-making to guide appropriate diagnostic testing or referral to a subspecialist. Nurses play a critical role in ongoing neurologic monitoring, identifying changes from baseline, reinforcing safety precautions, and promptly communicating concerning findings to the care team. Pharmacists contribute by evaluating medications that may influence neuromuscular function or reflex responses, such as sedatives or neurotoxic agents, and by supporting safe pharmacotherapy. Physical and occupational therapists assist in functional assessment and fall-risk reduction when neurologic impairment is suspected. Clear communication, timely escalation of abnormal findings, and coordinated care planning enhance diagnostic accuracy, promote patient safety, support early intervention for serious neurologic conditions, and strengthen overall team performance.