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Burning mouth syndrome (BMS) is characterized by burning pain in normal-appearing oral mucosa lasting at least four to six months. The condition is idiopathic, and the underlying pathophysiology is not well understood. This activity reviews the presentation of BMS and highlights the role of an interprofessional approach in its management. Objectives: Identify the etiology of burning mouth syndrome. Assess the presentation of patients with burning mouth syndrome and their evaluation. Evaluate the differential diagnosis of burning mouth syndrome. Access free multiple choice questions on this topic.

Burning mouth syndrome (BMS) is characterized by burning pain in a normal-appearing oral mucosa lasting at least 4 to 6 months.[1] The condition is idiopathic, and the underlying pathophysiology is not well understood. Patients with BMS commonly experience changes in gustatory function like parageusia. It is usually seen in females, typically in the peri-menopausal and post-menopausal periods.[2] The diagnosis is made clinically after other etiologies of mouth pain and changes in gustatory sensation are ruled out. Studies have shown an association of BMS with Axis I and Axis II psychiatric disorders,[3] psychiatric illness, structural and functional changes in the nervous system, and disruption of the circadian rhythm.[4] Disruptions in the circadian rhythm affect pain perception and mood and can disrupt the hypothalamic-pituitary-adrenal axis.[4] Lamey and Lewis categorized BMS into 3 categories based on fluctuations in pain severity over 24 hours: Type 1 typically has no symptoms on waking and progressively worsens throughout the day with variable nighttime symptoms. It may be related to nutritional deficiency or endocrine conditions such as diabetes mellitus. Type 2 is associated with chronic anxiety and displays symptoms throughout the day. Type 3 displays intermittent daytime symptoms and may have periods without any symptoms. Food allergy is thought to be a potential underlying mechanism.[5][6][7]

The etiology behind BMS is not well understood. Multiple theories exist regarding the underlying etiology, and most believe the condition to be multifactorial. As previously stated, the disease has a higher prevalence in peri- and postmenopausal women, which supports the theory that estrogen plays a role in the underlying process.[8] Decreased estrogen levels can lead to the atrophy of oral mucosal tissue, which may leave the area more susceptible to inflammatory change and the development of symptoms of BMS. In some cases, the infection may precede the development of symptoms, and certain pathogens are more commonly found in patients actively suffering from BMS, including Candida, Enterobacter, Fusospirochetal, Helicobacter pylori, and Klebsiella.[8] Diabetes mellitus and associated peripheral neuropathy may also cause symptoms related to BMS, although the underlying mechanism is neuropathy in this case. There is an association with certain irritants, including dental materials such as mercury, amalgam, methyl methacrylate, cobalt chloride, zinc, and benzoyl peroxide.[9] Also, certain food allergies, including peanuts, sorbic acid, chestnuts, and cinnamon, have been related to BMS.[10] As previously stated, there is a connection with patients with neuropsychiatric conditions such as major depression, chronic anxiety, and mood disorders. The most common association is with a major depressive disorder, and it may follow acute symptoms or share an association with a comorbid condition at some point in the patient's life.[3] Other causes include orthodontic appliances, possible prescription drug adverse effects, increased bradykinin, and comorbid dermatologic conditions.[4]

BMS is much more common in females than males, with 3 to 7 times higher occurrence. It has a strong association with advancing age in both sexes. The highest prevalence in females occurs in the perimenopausal and postmenopausal periods. The condition is non-existent in children and rarely seen in those under 30. Occurrence in males is rare before the fifth decade. Overall, the prevalence of BMS is not well documented but is thought to be around 4%.[8]

The pathophysiology behind BMS is poorly understood and may be related to psychogenic and neuropathic pathways. Disruptions in circadian rhythm, chronic anxiety, disruptions in the hypothalamic-pituitary-adrenal axis, irritants, infection, and diabetes mellitus are thought to contribute to its development. The underlying type of pain conduction is likely throughout the trigeminal distribution, and there is evidence of histopathologic changes in nociceptive nerves in patients displaying symptoms. Studies also show changes in taste perception and hot and cold sensation, which may have reflex hyperfunction to closely related nerve hypofunction. One study showed a link with the chorda tympani hypofunction, resulting in reduced taste while hyperstimulating the lingual nerve and causing symptoms. Other theories include mechanisms similar to phantom limb syndrome and small fiber neuropathy. Xerostomia in BMS is thought to be related more to neuropathy than a glandular issue. Mechanical damage from bruxism, clenching, and tongue thrusting may initiate symptoms, and psychiatric conditions most likely exacerbate symptoms.[11]

BMS is a diagnosis of exclusion. When taking a history, clinicians should rule out organic causes of oral pain and investigate the onset and duration of symptoms and associated medical conditions, medications, and history of oral prostheses. The absence of oral lesions is mandatory to diagnose BMS.[1]. The lack of consensus regarding BMS makes its diagnosis a difficult matter. Scala et al suggested 5 clinical criteria to diagnose BMS: Deep and bilateral burning pain is reported daily. Burning pain lasts for at least 4 to 6 months. Constant or increasing severity throughout the day. No worsening but improvement with eating and drinking. No sleep interference.[13] Additional criteria include taste disorder, xerostomia, sensory or chemosensory alterations, and mood or psychological disorders.[13] Most patients experience taste disorders such as perceiving a metallic or bitter taste.[14]

In a review of the diagnostic and therapeutic approach to BMS, R. Aravindhan, Santhanam Vidyalakshmi et al suggest a series of steps to diagnose the condition: Taking a careful history and quantifying the burning pain. Examining oral mucosa to rule out local and systemic causes of oral pain. Asking for information about psychological well-being. Measuring salivary rate and taste function with objective methods. Performing neurological examination and imaging to rule out degenerative disorders or other neurological pathologies. Taking oral cultures to rule out suspected bacterial, fungal, or viral infections. Performing allergy patch tests for allergic patients. Investigating for gastric reflux disease. Ruling out hormonal, autoimmune, and nutritional anomalies. It is worth noting that if the tongue looks normal during the examination, no biopsy is required - it is only indicated when a lesion is seen.[1][8]

Only after ruling out local and systemic causes of burning symptoms can the patient be considered as having BMS.[4] The management of such patients is complex, and more than 1 treatment modality is often required. Importantly, the patient should be aware that complete resolution of symptoms is not always possible. The current management options include topical and systemic medications and a newer approach: cognitive behavioral therapy. Despite the need for standardized guidelines, laser therapy has also reduced symptoms. Topical Medications Capsaicin is an analgesic used as a desensitizing agent that acts on the sensory afferent neurons to manage neuropathic pain.[15] Capsaicin has proven to improve burning symptoms compared to placebo groups in 3 studies.[16] However, increased burning sensation after its application, dyspepsia, and toxicity may limit its use.[1][4][1] Topical clonazepam successfully improves BMS symptoms.[17] It is applied by sucking a 1 mg tablet 3 times per day for 2 weeks [18]; however, symptoms may come back if the medication is discontinued, and it can cause dependence.[17] Dry mouth and fatigue are other possible side effects.[4] Interestingly, unconventional topical agents, including a mouth rinse of tabasco sauce with water [1] or hot pepper and water [19] have reduced burning symptoms. Also, 70% aloe vera gel was applied 3 times per day in combination with a tongue protector, effectively decreasing the tongue's burning symptoms.[20] Due to its short-term effect, topical anesthesia, like lidocaine, is not considered an effective treatment option.[1] Systemic Medications Low doses of clonazepam (0.5 mg per day) are frequently prescribed for treating BMS pain.[1] Systemic clonazepam relieves BMS pain but does not improve taste dysfunction, xerostomia, or mood.[21] It is a good option for short-term treatment since the chronic use of systemic clonazepam has not been deeply evaluated yet in this regard.[16] Systemic capsaicin can improve BMS symptoms but should be prescribed with caution because of its side effects, including gastric pain.[1]The regime consists of capsaicin 0.25% capsules 3 times daily for 4 weeks.[1]

Low doses of clonazepam (0.5 mg per day) are frequently prescribed for treating BMS pain.[1] Systemic clonazepam relieves BMS pain but does not improve taste dysfunction, xerostomia, or mood.[21] It is a good option for short-term treatment since the chronic use of systemic clonazepam has not been deeply evaluated yet in this regard.[16] Systemic capsaicin can improve BMS symptoms but should be prescribed with caution because of its side effects, including gastric pain.[1]The regime consists of capsaicin 0.25% capsules 3 times daily for 4 weeks.[1] Even though they contribute to xerostomia symptoms, tricyclic antidepressants – amitriptyline, desipramine, clomipramine, imipramine, and nortriptyline – can also be used in managing patients with BMS.[1] The regime consists of an initial 5 to 10 mg daily dose, gradually increasing to 50 mg daily.[1]. Furthermore, selective serotonin reuptake inhibitor antidepressants such as sertraline, paroxetine, and duloxetine result in a significant improvement in oral burning symptoms.[22][1][22] Antipsychotic drugs like amisulpride and levosulpiride show good patient compliance in short-term treatments and are proven to reduce patients’ burning symptoms (24-week course of 50 mg daily).[1] A study reported a complete resolution of symptoms after supplementation with vitamins BC, B12, folic acid, and minerals [23], which decreased mean serum homocysteine levels and increased hemoglobin levels in the blood.[23][1][23] Finally, hormone replacement therapy has been used to decrease oral burning symptoms in peri- and post-menopausal women.[24][1][24] Behavioral Modulation Relaxation and cognitive restructuring are 2 cognitive-behavioral therapy (CBT) techniques for BMS treatment. Patients learn focused breathing and muscle relaxation to alleviate pain using the relaxation technique.[25] Cognitive restructuring targets eliminating destructive thoughts – in the case of BMS, it aims at reducing pain catastrophizing [25], analyzing harmful automatic thoughts, and replacing them with more helpful ones.[25] Low-level Laser Therapy

Relaxation and cognitive restructuring are 2 cognitive-behavioral therapy (CBT) techniques for BMS treatment. Patients learn focused breathing and muscle relaxation to alleviate pain using the relaxation technique.[25] Cognitive restructuring targets eliminating destructive thoughts – in the case of BMS, it aims at reducing pain catastrophizing [25], analyzing harmful automatic thoughts, and replacing them with more helpful ones.[25] Low-level Laser Therapy Low-level laser therapy stimulates the production and secretion of serotonin and β-endorphins and decreases bradykinin secretion, alleviating burning symptoms.[25] Low-level lasers also inhibit the depolarization of C fibers, which are responsible for transmitting pain and heat stimuli.[26] Standardized treatment guidelines are needed and are yet to be developed.[26]

Multiple conditions may cause similar symptoms as BMS, including: Stomatitis, Atypical facial pain, Atypical odontalgia, Idiopathic facial arthromyalgia Pemphigoid Pemphigus Oral neoplastic lesions Acoustic neuroma Failed denture design or tooth restoration Herpes simplex Herpes zoster Post-surgical trauma to the lingual or mandibular nerve[27][13][8]

The prognosis is variable and based on the underlying mechanism and comorbidity. While some cases are transient and resolve with symptomatic treatment and time, symptoms can persist for months to years or never resolve. The disease is not progressive or known to cause further damage.

BMS is a chronic condition that can remit spontaneously, improve moderately, or even worsen with time. Patients with BMS suffer from chronic burning pain, sometimes accompanied by xerostomia and taste disorders, significantly impairing their quality of life. The etiopathogenesis of the condition is yet to be understood; therefore, treatment is challenging, and no individual approach can fully resolve symptoms, frustrating patients and clinicians.

BMS most likely appears in middle-aged and elderly females, mainly those going through peri and post-menopause.[2] BMS rarely occurs in patients under 30 and has never been seen in children and adolescents.[28] It is a diagnosis of exclusion. BMS cannot be diagnosed if any local or systemic conditions can justify the cause of the burning symptoms.[4] The oral mucosa must be free of lesions or anomalies to diagnose BMS.[4] BMS is a complex and poorly understood disease requiring more than 1 treatment approach. Therefore, clinicians should manage patients' expectations regarding treatment outcomes.

Diagnosing and managing BMS are challenging and require a multidisciplinary approach - medical and psychological. The cause of the disorder remains unknown, and the treatment is empirical. Treatment is focused on the underlying and associated conditions and symptomatic management. The overall prognosis for patients with BMS is guarded. Some patients improve without treatment, and others lead a poor quality of life with no relief from symptoms.[29][30]