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Panniculitis encompasses several cutaneous diseases characterized by inflammation of the subcutaneous fat. Clinically, panniculitis manifests with tender subcutaneous erythematous nodules or plaques, most often on the lower extremities. Panniculitis encompasses a heterogeneous group of disorders that may produce similar physical findings. Thus, diagnosis can be difficult without histopathological correlation. Prompt identification and diagnosis are essential to improve morbidity and mortality. Management of panniculitis involves supportive measures, pharmacotherapy, and addressing the underlying cause. Surgical intervention may be indicated for complications such as necrosis and abscess. This activity for healthcare professionals is designed to enhance competence in identifying the major forms of panniculitides, including septal and lobular panniculitis. This activity also describes the most appropriate biopsy technique for practitioners. Learners gain a deeper understanding of this condition's histopathological features and diagnostic algorithms. The role of the interprofessional healthcare team in evaluating, diagnosing, and treating patients with panniculitis is highlighted, thus empowering healthcare professionals with the necessary tools to provide optimal patient care and improve patient outcomes. Objectives: Identify the signs and symptoms indicative of panniculitis. Compare the histopathological features of septal and lobular panniculitis. Differentiate the most common causes of septal panniculitis based on histopathology findings. Collaborate with the interprofessional team to educate, treat, and monitor patients with panniculitis to improve patient outcomes. Access free multiple choice questions on this topic.

Panniculitis encompasses a wide variety of skin diseases characterized primarily by inflammation of the subcutaneous fat. The condition is not an extension of dermatoses of the dermis, such as morphea, or fascia, such as eosinophilic fasciitis, into the subcutis.[1] Panniculitis typically presents clinically with tender subcutaneous erythematous nodules or plaques, most often on the lower extremities. Additional features, such as sclerosis, ulceration, or atrophy, may also be noted depending on the subtype.[2] Panniculitis encompasses a heterogeneous group of rare disorders that may present with similar clinical features. Therefore, diagnosis can be difficult without histopathological correlation. Combining patient history, physical examination, and histopathological examination of a biopsy specimen is often necessary to diagnose panniculitides accurately and separate them from bruising and neoplasia.[3]