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The Wolffian ducts, or mesonephric ducts, are paired embryonic structures that serve as progenitors of the male internal genitalia and are involved in the incipient development of the renal system in both sexes. The Wolffian ducts develop in both male and female embryos but are maintained only in males by testosterone, and they give rise to the epididymis, vas deferens, and seminal vesicles.[1] Although the development of the Wolffian ducts into the male internal genitalia depends on testosterone, there is a dynamic, complex interplay among androgens, growth factors, gene expression in the duct epithelium, and the mesenchyme that is essential for the proper formation of the male reproductive tract.[1]