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An epidural blood patch (EBP) is a procedure in which a small volume of autologous blood is injected into a patient's epidural space to stop a leak of cerebrospinal fluid (CSF). This leak of CSF is thought to decrease CSF pressure, particularly when the patient is upright, allowing for increased cerebral blood flow via vasodilation producing a characteristic post-dural puncture headache (PDPH or "a spinal headache"). This activity reviews the indications, contraindications, and complications of an epidural blood patch and highlights the role of the interprofessional team in the management of patients with a post-dural puncture headache. Objectives: Describe how an epidural blood patch works. Review the indications for an epidural blood patch. Summarize the technique of administering the epidural blood patch. Explain the importance of improving care coordination among interprofessional team members to improve outcomes for patients with a post-dural puncture headache. Access free multiple choice questions on this topic.

An epidural blood patch (EBP) is a procedure in which a small volume of autologous blood is injected into a patient's epidural space to stop a leak of cerebrospinal fluid (CSF). This leak of CSF is thought to decrease CSF pressure, particularly when the patient is upright, allowing for increased cerebral blood flow via vasodilation producing a characteristic post-dural puncture headache (PDPH or "a spinal headache"). An alternate theory suggests that loss of CSF pressure, particularly with upright posture, creates traction on the cerebral meninges which is continuous with the vertebral meninges.[1][2] PDPHs occur when the dura has been violated. Typically this occurs following a subarachnoid injection (a "spinal"), or from inadvertent puncture of the dura when attempting epidural injection or placement of an epidural catheter. PDPHs can also occur following diagnostic or therapeutic procedures (diagnostic lumbar puncture, lumbar myelogram) or following spinal surgery. EBP is rarely used to treat "spinal" a headache following the creation of a dural rent following spine surgery. The incidence is less than 1% following the subarachnoid block performed with a 25-gauge spinal needle. This increases to nearly 36% when using a 20-gauge or 22-gauge needle for diagnostic lumbar puncture. Following inadvertent puncture of the dura with a 17-gauge epidural needle, the incidence of PDPH is approximately 75% to 80%. Risk factors include needle puncture size, age less than 60 years, and female gender. Typical onset is 24 to 48 hours following a puncture. A headache is often described as intense, vise-like in the frontal-occipital region and may be accompanied by cranial nerve symptoms of auditory impairment and/or blurred vision. Pathognomonic for PDPH is an aggravation of symptoms in an upright position with relief in a supine position. Left untreated more than 90% of PDPHs are self-limiting and will resolve spontaneously in 7 to 10 days. A prophylactic EBP following an inadvertent dural puncture in parturients for epidural catheter placement has not been shown to decrease the incidence of PDPH.

The incidence is less than 1% following the subarachnoid block performed with a 25-gauge spinal needle. This increases to nearly 36% when using a 20-gauge or 22-gauge needle for diagnostic lumbar puncture. Following inadvertent puncture of the dura with a 17-gauge epidural needle, the incidence of PDPH is approximately 75% to 80%. Risk factors include needle puncture size, age less than 60 years, and female gender. Typical onset is 24 to 48 hours following a puncture. A headache is often described as intense, vise-like in the frontal-occipital region and may be accompanied by cranial nerve symptoms of auditory impairment and/or blurred vision. Pathognomonic for PDPH is an aggravation of symptoms in an upright position with relief in a supine position. Left untreated more than 90% of PDPHs are self-limiting and will resolve spontaneously in 7 to 10 days. A prophylactic EBP following an inadvertent dural puncture in parturients for epidural catheter placement has not been shown to decrease the incidence of PDPH. Although many treatments including bed rest, analgesics, non-steroidal anti-inflammatory drugs (NSAIDs), hydration, intravenous (IV) caffeine, or consumption of caffeinated products have been used, these produce only temporary relief. The definitive treatment is performing an EBP with an approximately 85% success rate. EBP may be repeated and is reported to have a 90% success rate. In rare refractory instances, surgical exploration and placement of fat graft may be considered.[3][4][5]

The most frequent and problematic complications of EBP include failure (15 to 20%), worsening of PDPH by inadvertently creating additional dural rent(s), back pain, and infection. Mild to moderate back pain is commonly reported. This is self-limited, generally resolving in days and preferable to the discomfort of a PDPH. Also, patients need to be made aware of signs and symptoms of infection at the injection site: fever, malaise, erythema, or purulence as injected blood may serve as a nidus for infection. This requires urgent evaluation and care.[7][8][9]

Once PDPH has developed, healthcare workers including nurse practitioners, physician assistants, and primary care physicians should educate the patients. The majority resolve within 2 weeks. Other supportive measures include limiting upright position, hydration, oral analgesics, and intravenous or oral caffeine. Caffeine is a cerebral vasoconstrictor. It is administered as 500 mg sodium caffeine benzoate in 1000 mL of normal saline or lactated Ringer over 1 to 2 hours. This, however, generally produces short-term relief. A patient who chooses conservative therapy should keep well hydrated and consume caffeine-containing beverages and oral analgesics as necessary at home. The majority of patients who elect to have EBP are those that cannot minimize activity, for example, recent parturients with newborns or younger patients. Also, those patients that are extremely symptomatic (some cephalgia even when supine and cannot tolerate any degree of upright positioning, tearful or crying at rest, photophobia) will likely consent to EBP with or without conservative treatment. It is important to tell the patient that EBP is not 100% effective.[10] An interprofessional team approach to caring for these patients will produce the best results. [Level 5]