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Exenatide is FDA-indicated to improve glycemic control in adult patients with type 2 diabetes mellitus when used as an adjunct to diet and exercise. It is not recommended as first-line therapy to treat diabetes. However, clinical trials have shown Exenatide to be both safe and effective when used as monotherapy or in combination with other diabetic medications. Objectives: Describe the therapeutic mechanism of action of exenatide. Discuss exenatide's place in a diabetic therapy regimen, including administration and dosing options. Review the adverse event profile of exenatide. Outline interprofessional team strategies for improving care coordination and communication to advance diabetes management and improve outcomes using a GLP-1 receptor agonist like exenatide. Access free multiple choice questions on this topic.

According to the manufacturer, severe overdose has been shown to induce severe nausea, vomiting, and rapidly declining blood glucose concentrations. If an overdose occurs, clinicians should initiate appropriate supportive treatment. However, several case reports have recorded only gastrointestinal symptoms and little to no hypoglycemia.

Exenatide is FDA-indicated to improve glycemic control in adult patients with type 2 diabetes mellitus when used as an adjunct to diet and exercise. It is not recommended as a first-line therapy to treat diabetes. Clinical trials have shown exenatide to be safe and effective when used as either monotherapy or in combination with other diabetic medications. Clinical trials have demonstrated exenatide's ability to lower HbA1c and postprandial blood glucose in patients with type 2 diabetes mellitus.[7][8][9] While the drug is relatively safe, it is also expensive. The interprofessional healthcare team, including clinicians, mid-level providers, nurses, and pharmacists, should regularly educate patients on the importance of exercise and lowering body weight, which helps lower blood glucose and decreases the need for pharmacological agents. The patient should also be informed regarding the signs of adverse events so they can contact their clinician. The pharmacist can verify dosing and perform medication reconciliation to check for potential drug-drug interactions. It is essential to treat the underlying cause of the disease with lifestyle changes, with medication as an adjunct. Using interprofessional strategies will improve therapeutic results with exenatide and decrease adverse events. [Level 5]