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Given the full range of clinical applications of GABA receptor antagonists, interprofessional communication and care coordination are essential when using these medications. For example, physicians, mid-level practitioners, nurses, pharmacists, and other health professionals must be knowledgeable about treating benzodiazepine overdoses with flumazenil. However, flumazenil’s effects are inconsistent, and not all patients may respond. Additionally, anesthesiologists carry a significant responsibility to be well-versed regarding the use of GABA receptor antagonists as they may be used to reverse the effects of anesthesia. As research into different GABA receptor antagonists continues to expand their clinical utility, all health professionals must keep current on the research and clinical literature to provide patients with the highest quality of care. An interprofessional team that prioritizes communication, collaboration, and shared decision-making through an integrated, patient-centered approach can enhance outcomes and team performance, which leads to improved patient safety. Each interprofessional team member is responsible for identifying complications with the treatment of GABA receptor antagonists and responding appropriately and promptly to ensure the best possible patient prognosis and outcome.

In a healthcare setting, when a patient receives intravenous benzodiazepines, a nurse dedicated to monitoring the patient is essential. Also, resuscitative equipment, including flumazenil, must be available in the room before starting a procedure that utilizes these agents.