Browse the corpus

Jejunoileal atresia (JIA) is one of the common causes of intestinal obstruction in neonates. It has been generally reported that JIA occurs due to a vascular accident involving mesenteric blood supply in-utero. The atresia can be found anywhere on the small bowel, either as solitary or multiple lesions. Advancement in pediatric surgical techniques, pediatric anesthesia, intensive care unit (ICU) care, and nutritional supports over the years has led to better overall survival in patients with intestinal atresia. This activity highlights the role of the interprofessional team in the treatment of jejunoileal atresia, including improvement in surgical approaches, nutritional support, and postoperative care. Objectives: Identify the etiology of jejunoileal atresia. Review the appropriate evaluation of jejunoileal atresia. Outline the management options available for jejunoileal atresia. Summarize and explain the role of an interprofessional team involving the surgeons, anesthetists, nutritionists, neonatologists, and cardiologists for patients with cardiac anomalies in improving care coordination and communication to advance the overall patients outcomes in patients with jejunoileal atresia. Access free multiple choice questions on this topic.

Ileal and jejunal atresias are usually described together as jejunoileal atresia (JIA). JIA is a common cause of intestinal obstruction in neonates.[1] It occurs in 1 in 5,000 to 1 in 14,000 live births.[2] Intestinal atresia can occur at any location along the small bowel, as a solitary or multiple lesion. Distally located atresia usually presents with delayed symptoms compared to proximal ones. Occasionally, JIA is associated with other malformations such as cardiac anomalies, gastroschisis, and cystic fibrosis.[3][4][5] Evaluation can be initiated before birth with prenatal diagnosis, using ultrasound findings of intestinal obstruction, which are reported in 29% to 50% of cases.[2][6][7] Postnatally, the patient presents with signs and symptoms of intestinal obstruction, and a diagnosis is made with a plain abdominal radiograph, which shows proximal distended bowel with no distal bowel gas. Advances in pediatric anesthesia, pediatric surgery, intensive care, and nutritional support over the years have led to improved overall survival in patients with intestinal atresia.[6] Treatment is individualized in most cases and involves resuscitation with intravenous fluid, correction of electrolytes and acidosis, gastric decompression with a nasogastric tube, and operative intervention. The traditional surgical approach is transverse supraumbilical laparotomy, but in recent years, minimally invasive approaches such as circumumbilical incisions and laparoscopic-assisted techniques have been widely adopted. This topic aims to review the causes, course, clinical features, evaluation, and recent trends in the management of JIA.

The cause of JIA has been attributed to an intrauterine vascular accident involving branches of mesenteric vessels in the midgut.[8][9] The resultant ischemic necrosis of the fetal bowel is resorbed in utero, leaving behind a blind proximal and distal end of the bowel with a mesentery defect between the ends. Compared to distal vascular disruption, the more proximal vascular disruption results in more extensive bowel defects. There is experimental and clinical evidence supporting the in-utero vascular disruption hypothesis of JIA. Similar atresia was reproduced with induced vascular compromise in experimental animals.[10][11][12] Bile, lanugo hairs, and epithelial cells seen distal to the atretic segment may suggest that swallowing of amniotic fluid occurred before some events. Besides, atresia has been reported in other causes of in-utero vascular disruptions such as intussusception, internal hernia, midgut volvulus, omphalocele, and gastroschisis.[8][13][14][15][16][17] Thromboembolic occlusion of mesenteric vessels may have contributed in some situations, as shown by the increased risk of small intestinal atresia in mothers exposed to vasoconstrictive drugs and cigarette smoking in the first trimester of pregnancy.[8][18] The Grosfeld classification system describes 4 types of intestinal atresia.[19] Type I atresia is described as an internal membrane with serosa continuity and no mesenteric defect; type II involves a proximal and distal blind pouch connected by a fibrous cord with serosal discontinuity; type IIIa has serosa discontinuity with a V-shaped mesenteric defect only, and type IIIb is the apple peel deformity which described proximal jejunal atresia and a short ileal segment coiled around the ileocolic artery while multiple atresias characterize type IV.[6][19] The types of atresia hugely impact treatments and prognosis. Bowel loss is more common in type IIIb and type IV atresia. Type IIIb (Apple peel) atresia is the least common atresia, with a prevalence ranging from 5% to 10% in the literature.[2][6][20] Type IIIb atresias are more likely to be associated with volvulus, carry an increased risk of distal bowel vascular compromise, and have been seen in families demonstrating autosomal recessive inheritance.[2][10] Ileal atresias are rarer than jejunal atresias, and as the atresia becomes more distal, the frequency of occurrence decreases.[21]

The estimated prevalence of JIA ranges from 1 in 5000 to 1 in 14,000 live births. About 33% of the affected children are born prematurely, and JIA occurs equally in both sexes.[2][3][7][22] Familial cases of JIA have been reported, but the majority of JIA occurs sporadically.[23] Less than 10% of cases of JIA are seen with extra-abdominal organ abnormalities, which have been attributed to the late occurrence of localized vascular compromise in utero.[24] There are more associated anomalies, such as cystic fibrosis, malrotation, congenital heart disease, Down syndrome (trisomy 21), anorectal, and vertebral anomalies, reported for jejunal atresia compared with ileal atresia, where additional anomalies are rare.[3][4][5][24] No relationship between JIA and paternal or maternal diseases has been reported, and chromosomal abnormalities are seen in less than 1% of patients with JIA.[18][25]

Structural and functional abnormalities have been reported as part of the sequelae of the ischemic changes from the vascular accident seen in patients with JIA in addition to the gross changes in the anatomy of the intestine.[8][26][27] The proximal distended blind loop of the intestine is hypertrophied with normal-appearing villi but has defective peristalsis.[28][29] In both experimental animals and human newborns, there is a reduction in mucosal enzymes and adenosine triphosphatase activity, but hypertrophic and hypercellular ganglia with increased acetylcholinesterase activity in the bowel near the atretic segment.[28][29] The extent of JIA has been shown to depend on the location and size of vascular compromise, as demonstrated by a complete separation of the atretic ends of the bowel and the accompanying mesenteric defect between the ends seen when mesenteric vessels are disrupted close to the origin. In situations of incomplete vascular compromise, intestinal stenosis has been reported instead. Studies have shown that JIA is mostly due to local vascular events that can occur in situations that favor occlusion or kinking of blood supply to the intestine, such as internal hernias, volvuli, intussusceptions, different from duodenal atresia, which is usually seen in cases with associated malformation of other systems thereby implicating general factors such as fetal hypoxia instead of local factors as responsible. Historically, type II and type III JIA with blind ends have high mortality due to functional obstruction from defective peristalsis after direct anastomosis of proximal and distal blind ends.[8] The defective peristalsis and the mucosal necrosis of the blind ends seen in some cases of JIA are a result of vascular insufficiency.[8] It has been postulated that the damage done to the blind ends is not enough to cause the death of the areas, but being close to the infarcted part of the bowel, a conclusion can be drawn that these areas are left with insufficient blood supply.[8] Therefore, resection of the dilated proximal blind end and the proximal portion of the distal atretic end in JIA has been reported to yield better functional outcomes.

The histopathology in JIA is a proximal, distended, hypertrophied, blind loop of the intestine with normal-appearing villi but defective peristalsis.[28][29] The mean thickness of the inner circular muscle and outer longitudinal muscle layers of the proximal segment is higher within 3cm-5cm of the atretic end in both ileal and jejunal atresia. The interstitial cells of Cajal (ICC), which are important for gastrointestinal motility, are fewer in the proximal and distal atretic ends of JIA than in healthy bowel.[30] The concentrations of ICC vary across locations on the proximal segment, with the number of ICC at 8 cm greater than at 3 cm and 5 cm of the proximal segment in JIA [30]. In both experimental animals and human newborns, there is a reduction in mucosal enzymes and adenosine triphosphatase activity, but hypertrophic and hypercellular ganglia with increased acetylcholinesterase activity in the bowel near the atretic segment.[28][29]

A complete history and physical examination are needed for the diagnosis of JIA. History includes gestational age at birth, complications during pregnancy, family history, co-morbidities, illicit drug use, the result of prenatal screening, such as ultrasound evidence of obstruction like polyhydramnios, dilated bowel, and congenital anomalies such as Down syndrome. Perinatal history, including problems with the delivery, feeding history, onset of abdominal distension, bilious or non-bilious emesis, and passage of meconium, should be documented. Physical examination should include a general assessment of the severity of illness, abdominal distension, evidence of peritonitis, respiratory compromise from aspiration or splitting of the diaphragm, signs of dehydration, jaundice, and congenital anomalies, such as Down syndrome, congenital heart disease, and anorectal malformation.

Intestinal atresia may be suspected in-utero with suspicious prenatal ultrasound findings, and in a neonate, obstructive symptoms such as abdominal distension and bilious emesis are usually the presenting symptoms. Prenatal detection of JIA on ultrasound, based on evidence of intestinal obstruction, has been reported in some series, with detection rates ranging from 29% to 50%.[2][6][7] JIA may be seen on ultrasound as polyhydramnios, ascites, dilated bowel loops, and enhanced bowel echogenicity.[31][32][33] Prenatal diagnosis may enhance care by preparing clinicians and parents so that the neonate can receive prompt care, and complications associated with early feedings, such as emesis, electrolyte imbalance, and aspiration, can be avoided. Prenatal ultrasound has low sensitivity, especially for distal lesions; it cannot determine the number of atresias or identify the location of the obstruction, and is not capable of assessing the viability of the gut distal to the obstruction. Lesions in the proximal intestine (jejunum) are more likely to be detected than lesions in the distal lesion, which results from proximal bowel dilation from net swallowed amniotic fluid.[34][35] Postnatally, JIA presents with signs and symptoms of intestinal obstruction such as abdominal distension, emesis, and in some cases, delayed passage of meconium. Normal appearing meconium may be seen, but most often, light-colored plugs are passed from the rectum. As seen in type III b, blood may be present in the rectum in cases of distal bowel ischemia.

Postnatally, JIA presents with signs and symptoms of intestinal obstruction such as abdominal distension, emesis, and in some cases, delayed passage of meconium. Normal appearing meconium may be seen, but most often, light-colored plugs are passed from the rectum. As seen in type III b, blood may be present in the rectum in cases of distal bowel ischemia. Radiographic examination of the abdomen with plain abdominal X-ray using swallowed air as a contrast is a useful diagnostic tool. For proximal JIA, there are a few dilated proximal bowel segments with no distal gas. Intraperitoneal calcification can be seen in prenatal bowel perforation or meconium peritonitis. Malrotation is ruled out using an upper gastrointestinal series contrast study. A contrast enema is used to reveal the atypical appearance of the colon, as may be seen in meconium ileus or Hirschsprung disease. If the contrast passes into the dilated bowel loop, atresia is ruled out. Other studies, such as an echocardiogram, renal ultrasound, rectal biopsy, and cystic fibrosis screening, may be used to evaluate patients for associated congenital anomalies, including cardiac malformations, renal anomalies, Hirschsprung disease, and cystic fibrosis.

Following confirmation or suspicion of the diagnosis of JIA, preoperative management includes decompression with a nasogastric tube, fluid and electrolyte resuscitation, and intravenous broad-spectrum antibiotics in the event of perforation or evidence of infection. The surgical approach depends on the location of the lesion, the anatomy, intraoperative condition, and the remaining bowel length.[7] The most common technique is resection of the proximal dilated and atretic bowel, followed by primary end-to-end anastomosis, with or without tapering enteroplasty of the proximal bowel.[10][36][37] The decision to perform a temporary ileostomy is individualized and made when there is questionable bowel viability, a significant size discrepancy between the proximal and distal bowel, or intestinal perforation.[6][7][38] Surgery can be laparoscopic-assisted or open, and the decision for the surgical approach depends on the surgeon's preference, the patient's presentation, and anatomy. In a laparoscopic-assisted approach, the bowel is exteriorized through the umbilical incision and returned into the abdominal cavity after primary anastomosis. In open surgery, traditional transverse supra- or infraumbilical incisions are used; however, a circumumbilical incision is cosmetically better while producing the same outcomes as the transverse abdominal incisions.[39] One retrospective study reported shorter operative time, time to start, and time to full enteral feeding with the laparoscopic-assisted approach compared with open surgery. Still, there were no differences in postoperative complications, morbidity, or mortality between the 2 groups.[20][38] However, if the proximal small bowel is significantly distended, laparoscopy has limited utility as the neonatal bowel can be exteriorized through a significantly small incision. Two specific caveats are the child with multiple segmental atresias and the child with the atretic lesions separated by a short segment. Primary surgical repair is usually performed for multiple atresias to preserve bowel length (generally with a proximal protective diversion to allow the numerous distal anastomoses time to heal). In patients with atresia separated by a short segment, resection of the short atresia with primary anastomosis is advocated to reduce the number of intestinal anastomoses, provided the patient has sufficient intestinal length.

Conditions such as intestinal malrotation with midgut volvulus, internal hernia, congenital small left colon syndrome, Hirschsprung disease, meconium ileus, and colonic atresia present with signs and symptoms of bowel obstruction similar to jejunoileal (JIA). Many patients with malrotation may be asymptomatic but are at increased risk of midgut volvulus. Volvulus can present at any age, but is seen in 30% of children under 1 month old.[40] Both volvulus and JIA present with emesis, and malrotation is excluded using the upper gastrointestinal series. Most presentations of Hirschsprung disease are seen during the neonatal period, with signs and symptoms of intestinal obstruction or persistent abdominal obstruction following surgical anastomosis of small bowel at the JIA site. Contrast enema and rectal biopsy are utilized to exclude Hirschsprung disease from other causes of intestinal obstruction. In cystic fibrosis patients, meconium ileus is an important cause of intestinal obstruction, with a presentation similar to JIA. Like JIA, prenatal screening for cystic fibrosis and prenatal ultrasound findings with evidence of meconium ileus should trigger early workup and management to minimize complications associated with cystic fibrosis.[41]

The mortality for patients with JIA has approached zero over the past several years.[31] Advancements in pediatric anesthesia, surgical technique, and total parenteral nutrition have been credited with reduced morbidity and mortality. The prognosis of JIA depends on the presence of short bowel syndrome (SBS) with an intestinal length of less than 25cm, requiring long-term parenteral nutrition.[6] The risk for SBS is higher in patients with type III and type IV JIA. JIA accounts for about 10% of cases of intestinal failure, and the 2 most common bowel lengthening procedures are serial transverse enteroplasty (STEP) and longitudinal intestinal lengthening (LILT).[6] SBS and cardiac anomalies have been largely responsible for morbidity and mortality.[2][18] In type IIIb JIA, poor outcomes are associated with prematurity, low birth weight, and associated anomalies.[20] Type IV (multiple-segment atresia) is associated with central nervous system dysfunction in 25% of nonfamilial cases and with severe immunodeficiency linked to a mutation in the tetratricopeptide repeat domain-7A (TTC7A) gene.[42][43][44] The familial form of type IV is fatal and is associated with prematurity and reduced intestinal length.[45][46]

Postoperative complications include sepsis and anatomic leak, with varying rates across studies; reported rates of 5% to 8% and 5% to 7%, respectively, were observed in 2 retrospective studies.[6] Other important complications include adhesive bowel obstruction and short bowel syndrome (SBS). SBS is one of the major complications with a prolonged hospital stay, including more feeding problems, increased infection rate, morbidity, and mortality compared to patients without SBS.[6]

JIA is a condition where there is no opening or passage through a segment of the small intestine (jejunum and atresia). It occurs in 1 in 5000 to 1 in 14,000 live births, with equal incidence in males and females. It is generally accepted that JIA is caused by an in-utero vascular accident during fetal development. It may be associated with other anomalies such as cystic fibrosis and cardiac abnormalities. Prenatal screening with ultrasound demonstrates evidence of intestinal obstruction in 29% to 50% of cases. At delivery, the infant should not be fed if this diagnosis is suspected prenatally. However, if the infant is fed, there are episodes of emesis and abdominal distension. Diagnosis is made using an abdominal radiograph, which showed air in the proximal small intestine and no air distally. Upper gastrointestinal series and a contrast enema are performed to exclude other conditions, such as malrotation and Hirschsprung disease. Conditions that mimic this condition are malrotation with midgut volvulus, internal hernia, meconium ileus, and Hirschsprung disease. Treatment is with surgical intervention. Following surgical intervention, the infant is first stabilized by rehydration and correction of electrolytes and placement of nasogastric or orogastric tubes to remove fluid from the obstructed stomach and small intestine. The procedure is performed either through a laparoscopic-assisted approach or through an open surgical approach with a single incision on the abdomen. The blockage in the small intestine is identified, and the abnormal part of the intestine is resected and removed, after which the proximal and distal ends are joined together. Postoperatively, nasogastric tube drainage is continued, along with nothing by mouth. It takes the bowel days or even weeks to begin normal function. Oral feeding is started when a small amount of fluid passes through the nasogastric tube.  Pain is controlled with acetaminophen or ibuprofen, or opioids for more intense pain. The risks associated with surgical anastomosis include bowel anastomotic leak, wound infection, prolonged bowel recovery, and shortened intestinal length.

Postoperatively, nasogastric tube drainage is continued, along with nothing by mouth. It takes the bowel days or even weeks to begin normal function. Oral feeding is started when a small amount of fluid passes through the nasogastric tube.  Pain is controlled with acetaminophen or ibuprofen, or opioids for more intense pain. The risks associated with surgical anastomosis include bowel anastomotic leak, wound infection, prolonged bowel recovery, and shortened intestinal length. At home, the child continues a normal diet for age, unrestricted activity, and the incisions can be washed with water and soap. Do not submerge under water for at least a week after surgery, when the wound must have healed. Give pain medication as needed for pain control. Call your doctor or bring your child to the hospital if you notice redness, warmth, or drainage from the incision, vomiting, or fever. Follow up with your surgeon in 2 to 4 weeks after surgery for wound checks.

Historically, JIA is associated with high mortality and morbidity. However, advances in pediatric anesthesia, surgical techniques, intensive care, and nutritional support over the years have led to improved overall survival in patients with intestinal atresia. Resection of the dilated proximal intestine with end-to-end anastomosis, with or without tapering of the proximal intestine, is an advanced surgical technique that has been shown to prevent the high mortality associated with proximal bowel dysmotility and the resultant chronic obstruction. Understanding the proximal bowel dysfunction followed by the improvement in the surgical technique, along with total parenteral nutrition, has been vital in improving the prognosis of JIA. Prevention of JIA might not be possible. Still, close monitoring of high-risk pregnancies and prenatal screening with ultrasound would be helpful for the early diagnosis and prevention of complications.

JIA is the most common cause of intestinal obstruction in neonates. It has been generally reported that JIA occurs due to a vascular accident involving the mesenteric blood supply in utero. The atresia can be found anywhere in the small bowel, either as solitary or multiple lesions. Advancements in pediatric surgical techniques, pediatric anesthesia, intensive care unit care, and nutritional support over the years have led to better overall survival in patients with intestinal atresia. While the surgeon may have primary responsibility for the patient's care, other members of the interprofessional team include neonatologists, pediatric anesthesiologists, nutritionists, pediatric nurses, and other consultants, such as cardiologists or pulmonologists, for patients with associated cardiac anomalies and respiratory problems from cystic fibrosis. Each member of the team contributes to the overall care of the patients. Nurses closely monitor the patient's vital signs and provide nursing care. Neonatologists provide neonatal care, especially for patients admitted to neonatal intensive care units. Pharmacists are important team members in ensuring that patients are on appropriate analgesics and in maintaining antibiotic stewardship. Nutritionists determine each patient's nutritional requirements and make appropriate recommendations. Consultants such as cardiologists and pulmonologists are tasked with managing cardiac and pulmonary complications from associated anomalies.