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Koilocytosis is a descriptive term derived from the Greek adjective koilos, meaning hollow. Koilocytosis is pathognomonic, though not required, for the diagnosis of low grade squamous intraepithelial lesion (LSIL). Koilocytes are squamous epithelial cells with perinuclear cavitation and nuclear features of LSIL, to include nuclear enlargement, coarse chromatin, and irregular nuclear membranes. A rim of condensed cytoplasm often surrounds the perinuclear cavitation, giving the cell a "halo" or cleared-out appearance around the dysplastic nucleus. Researchers and pathologists have identified koilocytic cells in epithelium throughout the body, but the initial description came from cervical samples.[1] Cervical koilocytosis has since formed the basis for much of the research surrounding koilocytes, including their etiology and significance.[2]