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Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor that has been prescribed for nearly 30 years to manage hypertension and reduce cardiovascular strain. As a competitive ACE inhibitor, lisinopril prevents the conversion of angiotensin I to angiotensin II, a potent vasoconstrictor. This activity reviews lisinopril's mechanism of action, highlighting its distinct pharmacokinetic parameters and half-life compared to other ACE inhibitors. The discussion also includes lisinopril's FDA-approved indications, off-label uses, contraindications, drug-drug interactions, and potential toxicity. Additionally, dosage recommendations, warnings, and necessary patient monitoring protocols are outlined to support safe administration. This activity also emphasizes the critical role of an interprofessional healthcare team in managing hypertension with lisinopril. Objectives: Determine the mechanism of action of lisinopril in the context of hypertension management. Identify the various indications for prescribing lisinopril therapy. Assess potential adverse effects associated with lisinopril and strategies for monitoring and managing these effects. Develop collaboration and communication among interprofessional team members to improve the outcomes and treatment efficacy for patients receiving lisinopril therapy. Access free multiple choice questions on this topic.

As lisinopril metabolism depends on renal excretion, overdose management consists of general supportive care. However, gastric emptying strategies, intravenous fluids, vasopressors, and hemodialysis may also be considered when appropriate. Maintaining optimal blood pressure using fluids is critical for hypotensive patients.[22] Some reports suggest using angiotensin II administration as an alternative supportive treatment for the treatment of ACE inhibitor overdose.[23] There is no antidote available for lisinopril.

Lisinopril has been available for 3 decades and is a relatively safe medication for hypertension. Primary care clinicians, emergency department physicians, internists, and cardiologists often prescribe it. However, the drug requires monitoring. Potassium levels and renal function need periodic monitoring, which clinicians and nursing staff can oversee. Patients should understand how to avoid high-potassium diets, an area where clinicians, nurses, and pharmacists can provide counsel. Women need to be aware of the potential adverse effects of pregnancy while taking lisinopril, making interprofessional counsel from clinicians, nurses, and pharmacists vital. Pharmacists should also check for possible interactions and answer any patient questions. Even though lisinopril is a common and well-tolerated drug, an interprofessional team must optimize safety and therapeutic outcomes while minimizing or preventing adverse events.