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Situs inversus totalis (SIT) is a rare congenital condition characterized by mirror-image transposition of thoracic and abdominal organs. This anatomical variation often delays diagnosis of abdominal pathologies such as acute cholecystitis and cholelithiasis due to atypical symptom presentation. We conducted a systematic literature review with strict exclusion criteria, including 23 studies focused on benign indications. Our findings suggest that robotic assistance in laparoscopic cholecystectomy reduces risks associated with traditional approaches, improving operative ease and patient outcomes.