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©2013 UpToDate ® Print Email AJCC staging system for soft tissue sarcoma Primary tumor (T) T1 T1a Superficial tumor* T1b Deep tumor* T2 Tumor greater than 5 cm in greatest dimension T2a Superficial tumor T2b Deep tumor Regional lymph node (N) N0 No histologically verified metastasis to regional lymph nodes N1 Histologically verified regional lymph node metastasis Distant metastasis (M) M0 No distant metastasis M1 Distant metastasis Histologic grade of malignancy (G) G1 Low, well differentiated G2 Intermediate, moderately well differentiated G3 High, poorly differentiated G4 Poorly differentiated or undifferentiated (4-tier systems only) Stage grouping Stage I T1a, b N0 M0 G1-2 (G1 with a 3-tier system) T2a, b N0 M0 G1-2 (G1 with a 3-tier system) Stage II T1a, 1b N0 M0 G3-4 (G2-3 with a 3-tier system) T2a N0 M0 G3-4 (G2-3 with a 3-tier system) Stage III T2b N0 M0 G3-4 (G2-3 with a 3-tier system) Stage IV Any T N1 M0 Any G Any T N0 M1 Any G * Superficial tumor is located exclusively above the superficial fascia without invasion of the fascia; deep tumor is located either exclusively beneath the superficial fascia, superficial to the fascia with invasion of or through the fascia, or both superficial yet beneath the fascia. Retroperitoneal, mediastinal, and pelvic sarcomas are classified as deep tumors. Used with the permission of the American Joint Committee on Cancer (AJCC), Chicago, Illinois. The original source for this material is the AJCC Cancer Staging Manual, Sixth Edition (2002) published by Springer-Verlag New York, Inc.