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©2013 UpToDate ® Print Email TNM staging for soft tissue sarcoma Primary tumor (T) TX Primary tumor cannot be assessed T0 No evidence of primary tumor T1 Tumor 5 cm or less in greatest dimension* T1a Superficial tumor T1b Deep tumor T2 Tumor more than 5 cm in greatest dimension* T2a Superficial tumor T2b Deep tumor Regional lymph nodes (N) NX Regional lymph nodes cannot be assessed N0 No regional lymph node metastasis N1• Regional lymph node metastasis Distant metastasis (M) M0 No distant metastasis M1 Distant metastasis Histologic grade (G)Δ GX Grade cannot be assessed G1 Grade 1 G2 Grade 2 G3 Grade 3 Anatomic stage/prognostic groups Stage IA T1a N0 M0 G1, GX T1b N0 M0 G1, GX Stage IB T2a N0 M0 G1, GX T2b N0 M0 G1, GX Stage IIA T1a N0 M0 G2, G3 T1b N0 M0 G2, G3 Stage IIB T2a N0 M0 G2 T2b N0 M0 G2 Stage III T2a, T2b N0 M0 G3 Any T N1 M0 Any G Stage IV Any T Any N M1 Any G Note: cTNM is the clinical classification, pTNM is the pathologic classification. * Superficial tumor is located exclusively above the superficial fascia without invasion of the fascia; deep tumor is located either exclusively beneath the superficial fascia, superficial to the fascia with invasion of or through the fascia, or both superficial yet beneath the fascia. • Presence of positive nodes (N1) in M0 tumors is considered Stage III. Δ FNCLCC System preferred. Used with the permission of the American Joint Committee on Cancer (AJCC), Chicago, Illinois. The original source for this material is the AJCC Cancer Staging Manual, Seventh Edition (2010) published by Springer New York, Inc.