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©2013 UpToDate ® Print Email Insulin receptor A ribbon diagram of the structure of the insulin receptor kinase domain (from Val 978 to Lys 1283) as determined through x-ray crystallography. The alpha helices are shown in red, the β strands in green, the side of chains of tyrosines 1158,1162, and 1163 are in yellow, the nucleotide binding loop is in orange, the catalytic loop is in dark blue, and the activation loop is in violet. The N and C termini are noted by N and C. An N- and a C-terminal lobe with a single connection can be seen. Courtesy of Jeffrey Flier, MD.