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©2013 UpToDate ® Print Email Captopril delays progression of moderately increased albuminuria (formerly called microalbuminuria) in diabetes Effect of captopril or placebo in 225 patients with type 1 diabetes mellitus, normal blood pressure, and moderately increased albuminuria (formerly called microalbuminuria). At two years, captopril slowed the rate of progression to overt, dipstick-positive proteinuria and lowered the albumin excretion rate (AER) compared to placebo. Data from The Microalbuminuria Study Group, Diabetologia 1996; 39:587.
©2013 UpToDate ® Print Email Captopril delays progression of moderately increased albuminuria (formerly called microalbuminuria) in diabetes Effect of captopril or placebo in 225 patients with type 1 diabetes mellitus, normal blood pressure, and moderately increased albuminuria (formerly called microalbuminuria). At two years, captopril slowed the rate of progression to overt, dipstick-positive proteinuria and lowered the albumin excretion rate (AER) compared to placebo. Data from The Microalbuminuria Study Group, Diabetologia 1996; 39:587. ACE inhibitor slows progression of diabetic nephropathy The effect of the administration of placebo or captopril to patients with type 1 diabetes with overt proteinuria and a plasma creatinine concentration equal to or greater than 1.5 mg/dL (132 µmol/L). The likelihood of a doubling of the plasma creatinine concentration (Pcr) was reduced by more than 50 percent in the captopril group. Data from Lewis EJ, Hunsicker LG, Bain RP, et al. N Engl J Med 1993; 329:1456.