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©2013 UpToDate ® Print Email ACE inhibitor slows progression of diabetic nephropathy The effect of the administration of placebo or captopril to patients with type 1 diabetes with overt proteinuria and a plasma creatinine concentration equal to or greater than 1.5 mg/dL (132 µmol/L). The likelihood of a doubling of the plasma creatinine concentration (Pcr) was reduced by more than 50 percent in the captopril group. Data from Lewis EJ, Hunsicker LG, Bain RP, et al. N Engl J Med 1993; 329:1456.