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©2013 UpToDate ® Print Email ACE inhibitor and calcium blocker therapy protect against progressive glomerulosclerosis in rats by different mechanisms Beneficial effect of antihypertensive therapy with the calcium channel blocker nifedipine and the angiotensin-converting enzyme inhibitor enalapril in rats with subtotal nephrectomy. At eight weeks, both drugs lowered the blood pressure to an equivalent degree and were associated with better maintenance of the glomerular filtration rate (GFR) and a lesser degree of glomerulosclerosis than untreated rats. However, the mechanism of protection appeared to be different: enalapril lowered the glomerular capillary pressure (PGC), while nifedipine minimized glomerular hypertrophy as manifested by a reduction in glomerular volume. Data from: Dworkin LD, Burstein JA, Parker M, et al. Kidney Int 1993; 43:808.