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contentuptodate· Content· item f19_46_20205

©2013 UpToDate ® Print Email ACE inhibitor more effective than hydralazine and nitrates in HF Enalapril is associated with diminished mortality when compared to the combination of hydralazine-isosorbide dinitrate (Hydral-IDN) in patients with moderate NYHA class II or III heart failure. (p = 0.016 at two years [18 versus 25 percent] and p = 0.08 at five years [48 versus 54 percent].) Data from: Cohn JN, Johnson G, Ziesche S, et al. N Engl J Med 1991; 325:303.