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©2013 UpToDate ® Print Email ACE inhibitor is more effective than triple therapy in protecting against experimental diabetic nephropathy Efficacy of antihypertensive therapy in diabetic rats in reducing the number of sclerotic glomeruli at 70 weeks. Triple therapy with hydrochlorothiazide, hydralazine, and reserpine was partially protective, but captopril was completely protective, with the degree of glomerulosclerosis being less than that in control (normal) rats (left column). Captopril also normalized the intraglomerular pressure (46 mmHg) versus 64 mmHg in untreated diabetic animals and 56 mmHg with triple therapy. Data from Anderson S, Rennke HG, Garcia DL, et al. Kidney Int 1989; 36:526.