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Walk the Even Hospital Database by book and chapter — the raw source passages that ground Ask, DDx, and the rest.
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©2013 UpToDate ® Print Email Pulse analysis of plasma ACTH in Cushing's disease Analysis of specimens sampled at 10-minute intervals for 24 hours in normal subjects (left four panels) and patients with Cushing's disease (right four panels) reveals that in Cushing's disease, the amplitude and duration, but not the frequency of ACTH secretory episodes are increased. Data from: van den Berg G, Frölich M, Veldhuis JD, Roelfsema F. Combined amplification of the pulsatile and basal modes of adrenocorticotropin and cortisol secretion in patients with Cushing's disease: evidence for decreased responsiveness of the adrenal glands. J Clin Endocrinol Metab 1995; 80:3750.