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Walk the Even Hospital Database by book and chapter — the raw source passages that ground Ask, DDx, and the rest.
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©2013 UpToDate ® Print Email Classification of adverse drug reactions Drug reaction Examples Reactions occurring in most normal patients, given sufficient dose and duration of therapy (type A) Overdose Hepatic failure (acetaminophen) Side effects Nausea, headache (with methylxanthines) Secondary or indirect effects GI bacterial alteration after antibiotics Drug interactions Erythromycin increasing theophylline/digoxin blood levels Drug hypersensitivity reactions restricted to a small subset of the general population (type B) Intolerance* Tinnitus after a single aspirin tablet Idiosyncrasy • (pharmacogenetics) G6PD deficiency: anemia after antioxidant drugs Immunologic drug reactions (allergy) Anaphylaxis from beta-lactam antibiotics GI: gastrointestinal; G6PD: glucose-6-phosphate dehydrogenase. * Side effects at subtherapeutic doses. • Drug effect not attributable to known pharmacologic properties of drug and not immune medicated. Reproduced with permission from: Celik G, Pichler WJ, Adkinson NF Jr. Drug Allergy. In: Middleton's Allergy Principles & Practice, 7th ed, Adkinson NF, et al (Ed), Mosby Elsevier, Philadelphia 2009. p.1205-1226. Illustration used with permission of Elsevier Inc. All rights reserved.