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©2013 UpToDate ® Print Email AHA scientific statement: Applications of physiologic measurements under study* Measurement of coronary artery pressure • To evaluate the significance of one or more possible culprit lesions in patients with multivessel disease. • To evaluate ostial or distal left main lesions and ostial right lesions that are not well visualized by angiography. • To guide the treatment of serial stenoses in a single coronary artery. • To determine the significance of a single treatable lesion in a diffusely diseased vessel. • To estimate prognosis after stent placement. • To assess the significance of a stenosis in patients with a recent (more than six days) myocardial infarction. • To assess lesions in patients with treated unstable angina. • To assess the collateral circulation. Measurement of coronary artery flow velocity by Doppler methods • To assess the microcirculation. • To assess endothelial function. • To assess myocardial viability in patients with acute myocardial infarction. Measurement of both coronary artery pressure and Doppler coronary artery flow velocity • To assess intermediate stenosis. • To assess the microcirculation. • To assess lesion compliance, as defined by the change in the pressure drop to velocity relationship. * Applications of physiologic measurements that have recommended during PCI by the 2005 ACC/AHA/SCAI guidelines are presented separately. Data from Kern, MJ, Lerman, A, Bech, JW, et al. Physiological assessment of coronary artery disease in the cardiac catheterization laboratory: a scientific statement from the American Heart Association Committee on Diagnostic and Interventional Cardiac Catheterization, Council on Clinical Cardiology. Circulation 2006; 114:1321.