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Walk the Even Hospital Database by book and chapter — the raw source passages that ground Ask, DDx, and the rest.
2 passages
©2013 UpToDate ® Print Email Sensitivity and specificity of different antinuclear antibodies Antibody ds DNA ss DNA Histone Nucleoprotein Sm RNP Ro La SLE Sen 70 percent 80 30-80 58 30 27 25-35 15 Spec 95 percent 50 mod 96 percent 82 percent 87-94 Drug LE Sen 80 95 50 1 percent low low Spec 1-5 percent 50 high mod RA Sen mod low 25 1 percent 47 low low Spec 1 percent mod low Scleroderma Sen <1 percent <1 percent <1 percent 20 Spec <1 percent low PM/DM Sen <1 percent <1 percent <1 percent low Spec <1 percent low Sjögren's Sen mod low mod 1-5 percent 5-60 8-70 14-60 Spec 1-5 percent mod low mod 87 94 Sen: sensitivity; Spec: specificity. Other associations: RNP: Mixed connective tissue disease (MCTD); Ro: Subacute cutaneous lupus erythematosus, Primary biliary cirrhosis, Vasculitis, Congenital heart block.
©2013 UpToDate ® Print Email Sensitivity and specificity of different antinuclear antibodies Antibody ds DNA ss DNA Histone Nucleoprotein Sm RNP Ro La SLE Sen 70 percent 80 30-80 58 30 27 25-35 15 Spec 95 percent 50 mod 96 percent 82 percent 87-94 Drug LE Sen 80 95 50 1 percent low low Spec 1-5 percent 50 high mod RA Sen mod low 25 1 percent 47 low low Spec 1 percent mod low Scleroderma Sen <1 percent <1 percent <1 percent 20 Spec <1 percent low PM/DM Sen <1 percent <1 percent <1 percent low Spec <1 percent low Sjögren's Sen mod low mod 1-5 percent 5-60 8-70 14-60 Spec 1-5 percent mod low mod 87 94 Sen: sensitivity; Spec: specificity. Other associations: RNP: Mixed connective tissue disease (MCTD); Ro: Subacute cutaneous lupus erythematosus, Primary biliary cirrhosis, Vasculitis, Congenital heart block. Sensitivity and specificity of different antinuclear antibodies Antibody PCNA Scl-70 PM-1 Mi-1 Jo-1 Ku Nucleoli Centromere SLE Sen 5 low low 26 Spec 95 Drug LE Sen low low Spec RA Sen low low Spec Scleroderma Sen low 15-20 low low 54 25-30 Spec high PM/DM Sen low low 30-50 low 30-50 Spec Sjögren's Sen 5 low Spec Sen: sensitivity; Spec: specificity. Other associations: Centromere: Limited systemic sclerosis (CREST syndrome).