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©2013 UpToDate ® Print Email ANCA results for pauci-immune crescentic glomerulonephritis in adults Clinical presentation Prevalence of PI-CGN PPV for PI-CGN NPV for PI-CGN Rapidly progressive glomerulonephritis* 47 percent (106/224) 98 percent 80 percent Hematuria, proteinuria, and creatinine >3 mg/dL 21 percent (181/862) 92 percent 93 percent Hematuria, proteinuria, and creatinine 1.5-3 mg/dL 7 percent (51/685) 77 percent 98 percent Hematuria, proteinuria, and creatinine <1.5 mg/dL 2 percent (13/768) 47 percent 99 percent Estimated positive predictive values (PPV) and negative predictive values (NPV) of ANCA results for pauci-immune crescentic glomerulonephritis (PI-CGN) in adults (>18 years old) with different clinical presentations using an assay approach (that has a 72.5 percent sensitivity and a 98.4 percent specificity). * This clinical presentation presumed from renal biopsy showing >50 percent of glomeruli with crescents. Adapted from Jennette, JC, Wilkman, AS, Falk, RJ, Kidney Int 1998; 53:796. ANCA results for pauci-immune crescentic glomerulonephritis in older adults Clinical presentation of patient Prevalence of PI-CGN PPV for PI-CGN NPV for PI-CGN Rapidly progressive glomerulonephritis* 66 percent (82/124) 99 percent 65 percent Hematuria, proteinuria, and creatinine >3 mg/dL 30 percent (147/497) 95 percent 89 percent Hematuria, proteinuria, and creatinine 1.5-3 mg/dL 11 percent (36/311) 85 percent 97 percent Hematuria, proteinuria, and creatinine <1.5 mg/dL 4 percent (7/195) 66 percent 99 percent Estimated positive predictive values (PPV) and negative predictive values (NPV) of ANCA results for pauci-immune crescentic glomerulonephritis (PI-CGN) in older adults (>50 years old) with different clinical presentations using an assay approach (that has a 72.5 percent sensitivity and a 98.4 percent specificity). * This clinical presentation presumed from renal biopsy showing >50 percent of glomeruli with crescents. Adapted from Jennette, JC, Wilkman, AS, Falk, RJ, Kidney Int 1998; 53:796. ANCA results for pauci-immune crescentic glomerulonephritis in children Clinical presentation Prevalence of PI-CGN PPV for PI-CGN NPV for PI-CGN Rapidly progressive glomerulonephritis* 48 percent (10/21) 98 percent 80 percent Hematuria, proteinuria, and creatinine >3 mg/dL 16 percent (6/38) 90 percent 95 percent Hematuria, proteinuria, and creatinine 1.5-3 mg/dL 15 percent (6/39) 89 percent 95 percent Hematuria, proteinuria, and creatinine <1.5 mg/dL 1 percent (1/162) 30 percent 100 percent

PPV for PI-CGN NPV for PI-CGN Rapidly progressive glomerulonephritis* 48 percent (10/21) 98 percent 80 percent Hematuria, proteinuria, and creatinine >3 mg/dL 16 percent (6/38) 90 percent 95 percent Hematuria, proteinuria, and creatinine 1.5-3 mg/dL 15 percent (6/39) 89 percent 95 percent Hematuria, proteinuria, and creatinine <1.5 mg/dL 1 percent (1/162) 30 percent 100 percent Estimated positive predictive values (PPV) and negative predictive values (NPV) of ANCA results for pauci-immune crescentic glomerulonephritis (PI-CGN) in children (<18 years old) with different clinical presentation using an assay approach (that has a 72.5 percent sensitivity and a 98.4 percent specificity). * This clinical presentation presumed from renal biopsy showing >50 percent of glomeruli with crescents. Adapted from Jennette, JC, Wilkman, AS, Falk, RJ, Kidney Int 1998; 53:796.

©2013 UpToDate ® Print Email ANCA results for pauci-immune crescentic glomerulonephritis in adults Clinical presentation Prevalence of PI-CGN PPV for PI-CGN NPV for PI-CGN Rapidly progressive glomerulonephritis* 47 percent (106/224) 98 percent 80 percent Hematuria, proteinuria, and creatinine >3 mg/dL 21 percent (181/862) 92 percent 93 percent Hematuria, proteinuria, and creatinine 1.5-3 mg/dL 7 percent (51/685) 77 percent 98 percent Hematuria, proteinuria, and creatinine <1.5 mg/dL 2 percent (13/768) 47 percent 99 percent Estimated positive predictive values (PPV) and negative predictive values (NPV) of ANCA results for pauci-immune crescentic glomerulonephritis (PI-CGN) in adults (>18 years old) with different clinical presentations using an assay approach (that has a 72.5 percent sensitivity and a 98.4 percent specificity). * This clinical presentation presumed from renal biopsy showing >50 percent of glomeruli with crescents. Adapted from Jennette, JC, Wilkman, AS, Falk, RJ, Kidney Int 1998; 53:796.