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©2013 UpToDate ® Print Email ANCA results for pauci-immune crescentic glomerulonephritis in children Clinical presentation Prevalence of PI-CGN PPV for PI-CGN NPV for PI-CGN Rapidly progressive glomerulonephritis* 48 percent (10/21) 98 percent 80 percent Hematuria, proteinuria, and creatinine >3 mg/dL 16 percent (6/38) 90 percent 95 percent Hematuria, proteinuria, and creatinine 1.5-3 mg/dL 15 percent (6/39) 89 percent 95 percent Hematuria, proteinuria, and creatinine <1.5 mg/dL 1 percent (1/162) 30 percent 100 percent Estimated positive predictive values (PPV) and negative predictive values (NPV) of ANCA results for pauci-immune crescentic glomerulonephritis (PI-CGN) in children (<18 years old) with different clinical presentation using an assay approach (that has a 72.5 percent sensitivity and a 98.4 percent specificity). * This clinical presentation presumed from renal biopsy showing >50 percent of glomeruli with crescents. Adapted from Jennette, JC, Wilkman, AS, Falk, RJ, Kidney Int 1998; 53:796.