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©2013 UpToDate ® Print Email ANCA results for pauci-immune crescentic glomerulonephritis in older adults Clinical presentation of patient Prevalence of PI-CGN PPV for PI-CGN NPV for PI-CGN Rapidly progressive glomerulonephritis* 66 percent (82/124) 99 percent 65 percent Hematuria, proteinuria, and creatinine >3 mg/dL 30 percent (147/497) 95 percent 89 percent Hematuria, proteinuria, and creatinine 1.5-3 mg/dL 11 percent (36/311) 85 percent 97 percent Hematuria, proteinuria, and creatinine <1.5 mg/dL 4 percent (7/195) 66 percent 99 percent Estimated positive predictive values (PPV) and negative predictive values (NPV) of ANCA results for pauci-immune crescentic glomerulonephritis (PI-CGN) in older adults (>50 years old) with different clinical presentations using an assay approach (that has a 72.5 percent sensitivity and a 98.4 percent specificity). * This clinical presentation presumed from renal biopsy showing >50 percent of glomeruli with crescents. Adapted from Jennette, JC, Wilkman, AS, Falk, RJ, Kidney Int 1998; 53:796.