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©2013 UpToDate ® Print Email Hypergranular variant of acute promyelocytic leukemia The malignant promyelocytes in the more common "hypergranular" variant of acute promyelocytic leukemia (APL) have characteristic large reddish-blue or dark purple granules in the cytoplasm. The nucleus is often folded, indented, or dumb-bell shaped. Courtesy of Richard A Larson, MD. Acute promyelocytic leukemia During treatment with tretinoin, malignant promyelocytes in acute promyelocytic leukemia (APL) begin to differentiate to neutrophils. The cells acquire secondary granules, and the nuclear chromatin becomes condensed. Courtesy of Richard A Larson, MD.
©2013 UpToDate ® Print Email Hypergranular variant of acute promyelocytic leukemia The malignant promyelocytes in the more common "hypergranular" variant of acute promyelocytic leukemia (APL) have characteristic large reddish-blue or dark purple granules in the cytoplasm. The nucleus is often folded, indented, or dumb-bell shaped. Courtesy of Richard A Larson, MD.