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PAC (pmol/L) 750 • 60 91 144 1000 80 122 192 ARR: aldosterone-renin ratio; PAC: plasma aldosterone concentration; PRA: plasma renin activity; DRC: direct renin concentration; SI: Systeme International. * Values shown are on the basis of a conversion factor of PRA (ng/mL-hour) to DRC (mU/liter) of 8.2. DRC assays are still in evolution, and in a recently introduced and already commonly used automated DRC assay, the conversion factor is 12. • The most commonly adopted cut-off values are shown in bold: 30 for PAC and PRA in conventional units (equivalent to 830 when PAC is in SI units) and 750 when PAC is expressed in SI units (equivalent to 27 in conventional units). Reproduced with permission from: Funder JW, Carey RM, Fardella C, et al. Case detection, diagnosis, and treatment of patients with primary aldosteronism: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2008; 93:3266. Copyright © 2008 The Endocrine Society.