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©2013 UpToDate ® Print Email Antiretroviral regimens postexposure prophylaxis following a nonoccupational exposure to HIV Preferred regimen Tenofovir-emtricitabine (Truvada) plus raltegravir (Isentress) Alternative regimens Tenofovir-emtricitabine (Truvada) plus ritonavir-boosted atazanavir (Reyataz) Tenofovir-emtricitabine (Truvada) plus ritonavir-boosted darunavir (Prezista) Additional possible regimens Rilpivirine-tenofovir-emtricitabine (Complera) Tenofovir-emtricitabine (Truvada) plus lopinavir-ritonavir (Kaletra) Lamivudine-zidovudine (Combivir) can be substituted for tenofovir-emtricitabine in situations in which tenofovir is contraindicated, eg, chronic renal insufficiency. These are recommendations of the authors and consistent with the 2012 United States DHHS guidelines for treatment of HIV-infected adults. Panel on Antiretroviral Guidelines for Adults and Adolescents. Guidelines for the use of antiretroviral agents in HIV-1-infected adults and adolescents. Department of Health and Human Services. 1-239. Available at file://www.aidsinfo.nih.gov/guidelines/html/1/adult-and-adolescent-treatment-guidelines/0/. Accessed 28 March 2012.